gene 1,454 words KG: NOXA
Contents

NOXA Gene (PMAIP1)

🧬 Gene Info
Gene SymbolPMAIP1
Full NamePMA-Induced mRNA 1
Chromosome18q21.32
Functionis a critical pro-apoptotic BH3-only protein that functions as a potent inducer of apoptosis.
Primary ExpressionUbiquitous; high expression in brain, especially in neurons
Amino Acids193 aa
PathwaysNF-κB
UniProt IDQ9Y2X9
NCBI Gene ID5366
Ensembl IDENSG00000141682
OMIM604958
GeneCardsPMAIP1
Human Protein AtlasPMAIP1
Alternative NamesNOXA, APR, PMD
TissueExpression Level
InteractionsBAX, PITX3, BCL2, MDM2, CDK4, ATF4
KG Connections31 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Glycosaminoglycan Template Disruption Approach
Score: 0.46
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.41

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (12)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: therapeutic_target
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: therapeutic_target
MDM2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

NOXA inhibits BAX
NOXA activates PITX3
NOXA activates BCL2
NOXA activates MDM2
NOXA activates CDK4
NOXA activates ATF4
NOXA activates CHOP
NOXA activates PUMA
NOXA therapeutic_target DRP1
NOXA expressed_in Parkinson