Contents

STX17 Gene

🧬 Gene Info

Gene Symbol	STX17
Full Name	Syntaxin 17
Chromosome	9q31.3
Protein Type	Structural Protein
Target Class	Structural Protein
Function	STX17-targeting drugs would enhance or modulate autophagosome-lysosome fusion by facilitating SNARE complex assembly, thereby improving autophagic clearance of misfolded proteins and damaged organe...
Mechanism of Action	STX17-targeting drugs would enhance or modulate autophagosome-lysosome fusion by facilitating SNARE complex assembly, thereby improving autophagic clearance of misfolded proteins and damaged organelles. This mechanism is particularly relevant for neurodegenerative diseases characterized by protein aggregation.
Druggability	Medium (0.46)
Clinical Stage	Phase II
Pathways	Apoptosis, Autophagy, Cell Cycle, Lysosomal Degradation, Mitophagy
UniProt ID	E9PQU9
NCBI Gene ID	55276
Ensembl ID	ENSG00000143891
OMIM	612598
GeneCards	STX17
Human Protein Atlas	STX17
Associated Diseases	Aging, Als, Alzheimer's disease, Cardiac, Ftd
Known Drugs/Compounds	donanemab, lecanemab, rapamycin
Interactions	ACAT1, ACOX1, ACTB, Adiponectin, ADIPOQ, AKT
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Autophagosome Maturation Checkpoint Control
KG Connections	1111 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph