concept

ACAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

354Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

ACAT1 is a concept in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 165 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameACAT1
Key Genes/ProteinsSOAT1
Related DiseasesLiver Invasion, Parkinson, Tumor, Cancer, Als

Wiki Pages (1)

Knowledge base pages for this entity

MCCC1 Gene

gene · 1829 words

Pathway Diagram

graph TD
    ACAT1["ACAT1"]
    ACAT1 -->|"activates"| Cancer["Cancer"]
    ACAT1 -->|"activates"| Tumor["Tumor"]
    ACAT1 -->|"activates"| liver_invasion["liver_invasion"]
    ACAT1 -->|"activates"| PI3K["PI3K"]
    ACAT1 -->|"activates"| ERBB2["ERBB2"]
    ACAT1 -->|"activates"| AKT["AKT"]
    ACAT1 -->|"activates"| ERBB3["ERBB3"]
    ACAT1 -->|"activates"| TP53["TP53"]
    ERK["ERK"] -->|"activates"| ACAT1
    GAIN["GAIN"] -->|"activates"| ACAT1
    LYSOSOME["LYSOSOME"] -->|"regulates"| ACAT1
    ELF3["ELF3"] -->|"activates"| ACAT1
    PI3K -->|"activates"| ACAT1
    TP53 -->|"activates"| ACAT1
    ERBB3 -->|"activates"| ACAT1
    AKT -->|"activates"| ACAT1
    PHGDH["PHGDH"] -->|"causes"| ACAT1
    CANCER["CANCER"] -->|"activates"| ACAT1

Outgoing (228)

TargetRelationTypeStr
Liver Invasioncontributes_tophenotype0.85
SOAT1inhibitsgene0.70
Parkinsonassociated_withdisease0.65
Tumorassociated_withdisease0.65
Canceractivatesdisease0.65

Incoming (126)

SourceRelationTypeStr
WIPI2associated_withgene0.60
PIK3C3associated_withgene0.60
KAT5associated_withgene0.60
MAP1LC3associated_withgene0.60
OPTNassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found