Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ACAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ACAT1 is a concept in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 165 entities in the SciDEX knowledge graph.
| Name | ACAT1 |
| Key Genes/Proteins | SOAT1 |
| Related Diseases | Liver Invasion, Parkinson, Tumor, Cancer, Als |
Knowledge base pages for this entity
graph TD
ACAT1["ACAT1"]
ACAT1 -->|"activates"| Cancer["Cancer"]
ACAT1 -->|"activates"| Tumor["Tumor"]
ACAT1 -->|"activates"| liver_invasion["liver_invasion"]
ACAT1 -->|"activates"| PI3K["PI3K"]
ACAT1 -->|"activates"| ERBB2["ERBB2"]
ACAT1 -->|"activates"| AKT["AKT"]
ACAT1 -->|"activates"| ERBB3["ERBB3"]
ACAT1 -->|"activates"| TP53["TP53"]
ERK["ERK"] -->|"activates"| ACAT1
GAIN["GAIN"] -->|"activates"| ACAT1
LYSOSOME["LYSOSOME"] -->|"regulates"| ACAT1
ELF3["ELF3"] -->|"activates"| ACAT1
PI3K -->|"activates"| ACAT1
TP53 -->|"activates"| ACAT1
ERBB3 -->|"activates"| ACAT1
AKT -->|"activates"| ACAT1
PHGDH["PHGDH"] -->|"causes"| ACAT1
CANCER["CANCER"] -->|"activates"| ACAT1| Target | Relation | Type | Str |
|---|---|---|---|
| Liver Invasion | contributes_to | phenotype | 0.85 |
| SOAT1 | inhibits | gene | 0.70 |
| Parkinson | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Depression | associated_with | disease | 0.65 |
| Ischemia | inhibits | disease | 0.65 |
| Stroke | inhibits | disease | 0.65 |
| liver_invasion | activates | phenotype | 0.64 |
| RB1 | associated_with | gene | 0.60 |
| ATG | associated_with | gene | 0.60 |
| P62 | associated_with | gene | 0.60 |
| KAT8 | associated_with | gene | 0.60 |
| LAMP2A | associated_with | gene | 0.60 |
| SNAP29 | associated_with | gene | 0.60 |
| RB1CC1 | associated_with | gene | 0.60 |
| P53 | associated_with | gene | 0.60 |
| KAT2A | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| FIP200 | associated_with | gene | 0.60 |
| ULK1 | associated_with | gene | 0.60 |
| KAT2B | associated_with | gene | 0.60 |
| HSP70 | associated_with | gene | 0.60 |
| SIRT1 | associated_with | gene | 0.60 |
| GAPDH | associated_with | gene | 0.60 |
| STX17 | associated_with | gene | 0.60 |
| CALCOCO2 | associated_with | gene | 0.60 |
| VAMP8 | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| RUBCN | associated_with | gene | 0.60 |
| CREBBP | associated_with | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| NBR1 | associated_with | gene | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Apoptosis | associated_with | pathway | 0.60 |
| PI3K | activates | gene | 0.60 |
| ERBB2 | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| ERBB3 | activates | gene | 0.60 |
| TP53 | activates | gene | 0.60 |
| MEIS1 | activates | gene | 0.60 |
| ELF3 | activates | gene | 0.60 |
| Akt | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| WIPI2 | associated_with | gene | 0.60 |
| PIK3C3 | associated_with | gene | 0.60 |
| KAT5 | associated_with | gene | 0.60 |
| MAP1LC3 | associated_with | gene | 0.60 |
| OPTN | associated_with | gene | 0.60 |
| TFEB | associated_with | gene | 0.60 |
| EP300 | associated_with | gene | 0.60 |
| HSPA8 | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| NDP52 | associated_with | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| HDAC6 | associated_with | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| ERK | activates | gene | 0.60 |
| GAIN | activates | gene | 0.60 |
| PHGDH | associated_with | gene | 0.60 |
| P62 | associated_with | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| LYSOSOME | regulates | gene | 0.60 |
| RB1 | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| UBIQUITIN | associated_with | gene | 0.60 |
| ATG | associated_with | gene | 0.60 |
| RB1CC1 | associated_with | gene | 0.60 |
| KAT2A | associated_with | gene | 0.60 |
| ACETYL-COA | associated_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| GAPDH | associated_with | gene | 0.60 |
| CALCOCO2 | associated_with | gene | 0.60 |
| NBR1 | associated_with | gene | 0.60 |
| VAMP8 | associated_with | gene | 0.60 |
| ULK1 | associated_with | gene | 0.60 |
| OPTINEURIN | associated_with | gene | 0.60 |
| KAT2B | associated_with | gene | 0.60 |
| STX17 | associated_with | gene | 0.60 |
| CREB | associated_with | gene | 0.60 |
| SNAP29 | associated_with | gene | 0.60 |
| HSP70 | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| LAMP2A | associated_with | gene | 0.60 |
| P53 | associated_with | gene | 0.60 |
| SIRT1 | associated_with | gene | 0.60 |
| CREBBP | associated_with | gene | 0.60 |
| RUBCN | associated_with | gene | 0.60 |
| FIP200 | associated_with | gene | 0.60 |
| ELF3 | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| TP53 | activates | gene | 0.60 |
| ERBB3 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||