concept

ACAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

355Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

5Experiments

1Debates

Summary

ACAT1 is a concept in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 165 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ACAT1
Key Genes/Proteins	ABCA1, ACETYL-COA, Actin, ADAM10, AKT, ALDH2
Related Diseases	Als, Alzheimer, Alzheimer's disease
Related Pathways	Akt

Pathway Diagram

graph TD
    ACAT1["ACAT1"]
    ACAT1 -->|"activates"| Cancer["Cancer"]
    ACAT1 -->|"activates"| Tumor["Tumor"]
    ACAT1 -->|"activates"| liver_invasion["liver_invasion"]
    ACAT1 -->|"activates"| PI3K["PI3K"]
    ACAT1 -->|"activates"| ERBB2["ERBB2"]
    ACAT1 -->|"activates"| AKT["AKT"]
    ACAT1 -->|"activates"| ERBB3["ERBB3"]
    ACAT1 -->|"activates"| TP53["TP53"]
    ERK["ERK"] -->|"activates"| ACAT1
    GAIN["GAIN"] -->|"activates"| ACAT1
    LYSOSOME["LYSOSOME"] -->|"regulates"| ACAT1
    ELF3["ELF3"] -->|"activates"| ACAT1
    PI3K -->|"activates"| ACAT1
    TP53 -->|"activates"| ACAT1
    ERBB3 -->|"activates"| ACAT1
    AKT -->|"activates"| ACAT1
    PHGDH["PHGDH"] -->|"causes"| ACAT1
    CANCER["CANCER"] -->|"activates"| ACAT1

Outgoing (227)

Target	Relation	Type	Str
Liver Invasion	contributes_to	phenotype	0.85
SOAT1	inhibits	gene	0.70
Tumor	associated_with	disease	0.65
Ischemia	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Tumor	therapeutic_target	disease	0.65
Parkinson	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Depression	associated_with	disease	0.65
Als	regulates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	regulates	disease	0.65
liver_invasion	activates	phenotype	0.64
SNAP29	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
ATG	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TP53	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
Mtor	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
AMPK	associated_with	gene	0.60
STX17	associated_with	gene	0.60
P53	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
Cell Cycle	associated_with	pathway	0.60
Chaperone	associated_with	pathway	0.60
PI3K	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
GAPDH	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
Akt	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60

Incoming (128)

Source	Relation	Type	Str
LRP1	interacts_with	gene	0.70
AMPK	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
EP300	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
P62	associated_with	gene	0.60
LC3	associated_with	gene	0.60
TP53	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
RB1	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
ACETYL-COA	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
STX17	associated_with	gene	0.60
CREB	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
P53	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
ERBB2	activates	gene	0.60
RAS	activates	gene	0.60
TREM2	inhibits	gene	0.60
DEPRESSION	associated_with	gene	0.60
GENES	associated_with	gene	0.60
APOE	associated_with	gene	0.60
ATG	associated_with	gene	0.60
MAPK	activates	gene	0.60
MEIS1	activates	gene	0.60
rapamycin	targets	drug	0.60
ERK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.604

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Folic acid-induced nephropathy model for hyperoside renoprotection	validation	chronic kidney disease	0.900	folic acid-induced nephropathy	proposed	N/A
Unilateral ureteral obstruction model for hyperoside treatment	validation	chronic kidney disease	0.900	unilateral ureteral obstructio	proposed	N/A
Hyperoside-ACAT1 direct binding interaction studies	exploratory	chronic kidney disease	0.850	in vitro protein-ligand bindin	proposed	N/A
Acat1 knockdown functional validation experiment	exploratory	chronic kidney disease	0.800	Acat1 knockdown cells/tissues	proposed	N/A
L-carnitine rescue experiments in metabolic pathway	exploratory	chronic kidney disease	0.800	ACAT1 knockdown with L-carniti	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The observation that salsalate and diflunisal decrease both AD and TBI incidence

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning ACAT1 in their description or question text

No additional research found