| Gene Symbol | ABCA1PROTEIN |
| Full Name | abca1-protein |
| Protein Type | Protein |
| Target Class | Transporter |
| Function | is a member of the ABC transporter family that plays a critical role in cholesterol efflux and lipid homeostasis throughout the body, including the central nervous system[@vasiliou2009]. |
| Mechanism of Action | Small molecule modulators to enhance cholesterol efflux and HDL formation |
| Primary Expression | many tissues, including liver, macrophages, microglia, astrocytes, and neurons |
| Druggability | Medium (0.47) |
| Clinical Stage | Approved |
| UniProt ID | Search UniProt |
| GeneCards | ABCA1PROTEIN |
| Human Protein Atlas | ABCA1PROTEIN |
| Two transmembrane domains (TMDs) | Each containing 6 transmembrane helices |
| Extracellular loops | Form the substrate entry portal for lipids |
| Intracellular loops | Connect TMDs and contain regulatory elements |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | 25-Hydroxycholesterol, CS-6253, dexamethasone, quercetin, statins |
| Interactions | 4E-BP1, abca2, ABCA2, ABCA4, ABCA7, ABCG1 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | HDL/apoE Particle Remodeling as a Therapeutic Swit APOE4 hypolipidation and ABCA1 mistrafficking impa ABCA1 Upregulation via LXRβ Agonism to Enhance Cho (+1 more) |
| KG Connections | 1179 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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