biomarker 1,155 words KG: CSF 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

CSF Biomarker Comparison Across Neurodegenerative Diseases

🔬 Protein Info
Gene SymbolCSF
What it measuresSynaptic degeneration
ADStrongly elevated
PDMild elevation
ALSElevated
FTDVariable
p-Tau181Most established, AD-specific (sensitivity 85%, specificity 85%)[@hansson2022]
p-Tau217Highest accuracy for AD (sensitivity 90%, specificity 88%)[@palmqvist2021]
p-Tau231Earliest detector in preclinical AD[@janelidze2020]
Associated DiseasesMULTIPLE SCLEROSIS
Known Drugs/CompoundsADUCANUMAB
KG Connections122 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Heterogeneous astrocyte activation states differentially imp
Score: 0.52
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Noradrenergic-Tau Propagation Blockade
Score: 0.51

Related Analyses (18)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Extracellular vesicle biomarkers for early AD detection
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (30)

FLS Stimulation and Transcriptomic Analysis
exploratory · proposed · Score: 0.95
iPSC-derived endothelial cell iron uptake with RLS CSF expos
exploratory · proposed · Score: 0.90
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90
CSF iron content analysis in RLS patients versus controls
clinical · proposed · Score: 0.85
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40

See Also (4)

Tau Consortium
organization · KG edge: expressed_in
Proteome Atlas for Neurodegenerative Diseases
mechanism · KG edge: contains
AQP4 (Aquaporin-4 Gene)
gene · KG edge: loss_affects
Neurodegeneration
disease · KG edge: regulates

Knowledge Graph (12 edges)

CSF contains PROTEOME
CSF contains PD_ProS
CSF activates AQP4
CSF inhibits MELANOMA
CSF associated_with TAU
CSF regulates TAU
CSF interacts_with SYK
CSF activates SYK
CSF stabilizes TAU
CSF produces TAU