biomarker 4,101 words KG: neurodegenerative disease 2026-03-24
kind:biomarkersection:biomarkersstate:publishedevidence:strong
Contents

Cerebrospinal Fluid (CSF) Biomarkers Overview

🔬 Protein Info
Gene SymbolCSF
[Tau Protein](/proteins/tau-protein)p-tau181, p-tau217, p-tau231
[Beta-Amyloid](/proteins/beta-amyloid)Aβ42/Aβ40 ratio
[TREM2](/proteins/trem2)Soluble TREM2 in CSF
DiagnosisSupporting clinical diagnosis of neurodegenerative diseases
ProgressionMonitoring disease progression
Clinical TrialsEnriching patient selection and measuring treatment response
Associated DiseasesMULTIPLE SCLEROSIS
Known Drugs/CompoundsADUCANUMAB
KG Connections122 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (26)

TREM2-mediated microglial tau clearance enhancement
Score: 0.49
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
TREM2-Dependent Microglial Senescence Transition
Score: 0.74
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.57

Related Analyses (30)

Extracellular vesicle biomarkers for early AD detection
neurodegeneration · archived
Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (22)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

CGG repeat expansions causes neurodegenerative disease
PPAR-γ treats neurodegenerative disease
ESRRA regulates neurodegenerative disease
ESRRG regulates neurodegenerative disease
PPAR implicated_in neurodegenerative disease
RELN implicated_in neurodegenerative disease
APOE implicated_in neurodegenerative disease
HCN4 implicated_in neurodegenerative disease
HCN2 implicated_in neurodegenerative disease
HCN1 implicated_in neurodegenerative disease