gene 751 words KG: HCN2 2026-03-22
kind:genesection:genesstate:published
Contents

HCN2 Gene - Hyperpolarization-activated Cyclic Nucleotide-gated Channel 2

🧬 Gene Info
Gene SymbolHCN2
Full NameHyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2
Chromosome19q13.4
FunctionHCN2 channels are voltage-gated cation channels that pass both Na+ and K+ currents with unusual gating properties.
Primary Expressionthe sinoatrial (SA) node and atrioventricular (AV) node
Molecular Weight95 kDa
UniProt IDQ9P0R3
NCBI Gene ID6138
Ensembl IDENSG00000145214
OMIM616383
GeneCardsHCN2
Human Protein AtlasHCN2
Pacemaker CurrentGenerates Ih, a depolarizing current activated by hyperpolarization
Resting PotentialContributes to setting and stabilizing the resting membrane potential
Synaptic IntegrationModulates dendritic integration and synaptic plasticity
Associated DiseasesAD, ALS, AMI, ARM, Absence Seizures
InteractionsJUN, HCN1, GENES, AND, EPILEPSY, App
KG Connections81 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47

Related Analyses (8)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (6)

Packard Center for ALS Research
institution · KG edge: associated_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
HCN1 Gene
gene · KG edge: associated_with
Genes
index · KG edge: causes

Knowledge Graph (12 edges)

HCN2 inhibits JUN
HCN2 associated_with HCN4
HCN2 inhibits HCN1
HCN2 associated_with HCN1
HCN2 implicated_in epilepsy
HCN2 implicated_in atrial fibrillation
HCN2 implicated_in degenerative disease
HCN2 implicated_in neurodegenerative disease
HCN2 implicated_in neurological diseases
HCN2 implicated_in neuropathic pain