gene 1,419 words KG: HCN4 2026-03-24
kind:genesection:genesstate:published
Contents

HCN4 — Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4

🧬 Gene Info
Gene SymbolHCN4
Full NameHyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4
Chromosome15q24.1
Protein TypeChannel
Functionis a transmembrane protein that forms homotetrameric ion channels.
Primary Expressionvarious brain regions where it contributes to neuronal excitability, rhythmic activity, and synaptic integration
Amino Acids919 aa
UniProt IDQ9Y3X5
NCBI Gene ID80216
Ensembl IDENSG00000138668
OMIM607272
GeneCardsHCN4
Human Protein AtlasHCN4
Genomic CoordinatesChr15:73,257,977-73,314,655 (GRCh38)
RefSeq mRNANM_001194
Associated DiseasesAD, ALS, AMI, ARM, Absence Seizures
InteractionsJUN, AND, EPILEPSY, App, HCN, GENES
KG Connections81 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.44

Related Analyses (7)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (6)

Packard Center for ALS Research
institution · KG edge: associated_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
HCN2 Gene - Hyperpolarization-activated Cyclic Nucleoti
gene · KG edge: associated_with
HCN1 Gene
gene · KG edge: associated_with
Genes
index · KG edge: causes

Knowledge Graph (12 edges)

HCN4 associated_with SINUS NODE DYSFUNCTION
HCN4 associated_with ATRIAL FIBRILLATION
HCN4 associated_with VENTRICULAR TACHYCARDIA
HCN4 associated_with ATRIOVENTRICULAR BLOCK
HCN4 implicated_in ABSENCE SEIZURES
HCN4 implicated_in EPILEPSY
HCN4 associated_with HCN2
HCN4 associated_with HCN1
HCN4 implicated_in epilepsy
HCN4 implicated_in atrial fibrillation