gene 1,152 words KG: ESRRA 2026-03-26
kind:genesection:genesstate:published
Contents

ESRRA (Estrogen-Related Receptor Alpha) Gene

🧬 Gene Info
Gene SymbolESRRA
Full NameESRRA (Estrogen-Related Receptor Alpha)
Chromosome11q13.1
Protein TypeGene
FunctionPGC-1α coactivates ERRα, which in turn drives the expression of nuclear-encoded mitochondrial genes - OXPHOS Regulation: Controls the expression of all five complex subunits of the electron transport
Primary Expressiontissues with high energy demands, including the brain, heart, skeletal muscle, and liver[2]
Amino Acids500 aa
Exons8
PathwaysMicrobiota
NCBI Gene IDSearch NCBI
GeneCardsESRRA
Human Protein AtlasESRRA
Associated DiseasesAlzheimer's disease
InteractionsPTEN, PINK1, ATG5, AUTOPHAGY, MITOPHAGY
KG Connections23 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (19)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51

Related Analyses (8)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

See Also (7)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: activates
PTEN Gene
gene · KG edge: activates
DKK1 — Dickkopf WNT Signaling Pathway Inhibitor 1
gene · KG edge: regulates
ATG5 — Autophagy Related 5
gene · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: implicated_in

Knowledge Graph (12 edges)

ESRRA regulates DKK1
ESRRA regulates neurodegenerative disease
ESRRA activates PTEN
ESRRA activates PINK1
ESRRA activates ATG5
ESRRA upregulates ATG5
ESRRA associated_with Alzheimer's disease
ESRRA activates AUTOPHAGY
ESRRA activates Autophagy
ESRRA activates Mitophagy