| Gene Symbol | ESRRA |
| Full Name | ESRRA (Estrogen-Related Receptor Alpha) |
| Chromosome | 11q13.1 |
| Protein Type | Gene |
| Function | PGC-1α coactivates ERRα, which in turn drives the expression of nuclear-encoded mitochondrial genes - OXPHOS Regulation: Controls the expression of all five complex subunits of the electron transport |
| Primary Expression | tissues with high energy demands, including the brain, heart, skeletal muscle, and liver[2] |
| Amino Acids | 500 aa |
| Exons | 8 |
| Pathways | Microbiota |
| GeneCards | ESRRA |
| Human Protein Atlas | ESRRA |
| N-terminal activation domain | Contains the AF-1 region for transcriptional activation |
| DNA-binding domain (DBD) | Two zinc finger motifs that recognize estrogen-related response elements (ERREs) |
| Hinge region | Flexible region allowing protein-protein interactions |
| Ligand-binding domain (LBD) | Contains the AF-2 activation domain; despite being an orphan receptor, it maintains a functional LBD capable of binding synthetic ligands |
| Associated Diseases | Alzheimer's disease |
| Interactions | ATG5, AUTOPHAGY, MITOPHAGY, PINK1, PTEN |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!