gene 2,636 words KG: ESRRG
Contents

ESRRG Gene

🧬 Gene Info
Gene SymbolESRRG
Full NameEstrogen-Related Receptor Gamma
Chromosome1q41
Protein FamilyNuclear receptor family, ERR subfamily
Protein TypeReceptor
Functionis an orphan nuclear receptor that functions as a transcriptional regulator of metabolism, mitochondrial biogenesis, and cellular energy homeostasis.
Primary Expressiontissues with high metabolic demand, including brain, heart, skeletal muscle, and kidney [@schreiber2003]
Exons13
UniProt IDQ9UH77
NCBI Gene ID2624
Ensembl IDENSG00000125520
OMIM605515
GeneCardsESRRG
Human Protein AtlasESRRG
Associated DiseasesAlzheimer's disease, Huntington
InteractionsDRD1, DRD2, LYSOSOME, SYNUCLEINOPATHY
KG Connections34 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
CYP46A1 Overexpression Gene Therapy
Score: 0.77
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Neurons
entity · KG edge: expressed_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
Genes
index · KG edge: activates
DKK1 — Dickkopf WNT Signaling Pathway Inhibitor 1
gene · KG edge: regulates
DRD1 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

ESRRG regulates DKK1
ESRRG regulates neurodegenerative disease
ESRRG inhibits DRD1
DRD2 inhibits ESRRG
DRD1 inhibits ESRRG
ESRRG expressed_in Striatum
ESRRG associated_with Alzheimer's disease
HUNTINGTON associated_with ESRRG
ESRRG associated_with AUTOPHAGY
ESRRG associated_with Huntington

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