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biomarker 1,749 words KG: CSF 2026-04-01
section:biomarkerskind:biomarkertopic:psptopic:cbstopic:alzheimerstopic:oga-inhibitortopic:target-engagementtopic:asian-populations
Contents

CSF O-GlcNAc — Target Engagement Biomarker for OGA Inhibitors

🔬 Protein Info
Gene SymbolCSF
SummaryCerebrospinal fluid O-GlcNAc as pharmacodynamic marker for O-GlcNAcase inhibitor trials
Associated DiseasesMULTIPLE SCLEROSIS
Known Drugs/CompoundsADUCANUMAB
KG Connections122 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (14)

SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54Aquaporin-4 Polarization Rescue
Score: 0.51Multi-Modal Stress Response Harmonization
Score: 0.60SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56

Related Analyses (6)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archivedExtracellular vesicle biomarkers for early AD detection
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (30)

FLS Stimulation and Transcriptomic Analysis
exploratory · proposed · Score: 0.95iPSC-derived endothelial cell iron uptake with RLS CSF expos
exploratory · proposed · Score: 0.90CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90CSF iron content analysis in RLS patients versus controls
clinical · proposed · Score: 0.85Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40

See Also (4)

Tau Consortium
organization · KG edge: expressed_inProteome Atlas for Neurodegenerative Diseases
mechanism · KG edge: containsAQP4 (Aquaporin-4 Gene)
gene · KG edge: loss_affectsNeurodegeneration
disease · KG edge: regulates

Knowledge Graph (12 edges)

CSF contains PROTEOME
CSF involved_in Glymphatic Pathway
CSF contains PD_ProS
CSF activates AQP4
CSF inhibits MELANOMA
CSF associated_with TAU
CSF regulates TAU
CSF interacts_with SYK
CSF activates SYK
CSF stabilizes TAU
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