biomarker 1,204 words KG: CSF 2026-03-31
kind:biomarkersection:biomarkersstate:publishedtopic:alzheimerstopic:parkinsonsevidence:strong
Contents

CSF Synaptic Biomarker Panel for Neurodegenerative Diseases

🔬 Protein Info
Gene SymbolCSF
Function SNAP-25 is a pre-synaptic terminal protein essential for synaptic vesicle fusion and neurotransmitter release. It forms the SNARE complex with syntaxin and synaptobrevin
GeneSYP
LocationSynaptic vesicles
CSF specificityHighly brain-specific
Elevation mechanismSynaptic terminal damage
FragmentCG-NP-25 (cleaved by neurotoxicity)
StabilityGood in CSF
SpecificityPan-neuronal
Associated DiseasesMULTIPLE SCLEROSIS
Known Drugs/CompoundsADUCANUMAB
KG Connections122 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Multi-Modal Stress Response Harmonization
Score: 0.60
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.49
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45

Related Analyses (21)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Extracellular vesicle biomarkers for early AD detection
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (30)

FLS Stimulation and Transcriptomic Analysis
exploratory · proposed · Score: 0.95
iPSC-derived endothelial cell iron uptake with RLS CSF expos
exploratory · proposed · Score: 0.90
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90
CSF iron content analysis in RLS patients versus controls
clinical · proposed · Score: 0.85
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40

See Also (4)

Tau Consortium
organization · KG edge: expressed_in
Proteome Atlas for Neurodegenerative Diseases
mechanism · KG edge: contains
AQP4 (Aquaporin-4 Gene)
gene · KG edge: loss_affects
Neurodegeneration
disease · KG edge: regulates

Knowledge Graph (12 edges)

CSF contains PROTEOME
CSF contains PD_ProS
CSF activates AQP4
CSF inhibits MELANOMA
CSF associated_with TAU
CSF regulates TAU
CSF interacts_with SYK
CSF activates SYK
CSF stabilizes TAU
CSF produces TAU