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cell 601 words KG: NEURONS
Contents

Lysosomal System in Neurons

🧫 Cell Type Info
Cell TypeNEURONS
Also Known AsNerve cell, Neuronal cell
FunctionsElectrical signal transmission, Synaptic neurotransmitter release, Neural circuit formation, Information processing and storage, Neuroendocrine signaling
Associated DiseasesAlzheimer's disease (neuronal loss), Parkinson's disease (dopaminergic neuron loss), ALS (motor neuron degeneration), Huntington's disease (striatal neuron loss), Epilepsy (hyperexcitability)
Related GenesALPHA-SYNUCLEIN, APP, CD2AP, DRD2
Linked Hypotheses675 hypotheses

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Wikipedia

Related Hypotheses (16)

The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62APOE-Dependent Autophagy Restoration
Score: 0.89Senescent Cell Mitochondrial DNA Release
Score: 0.74Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Lysosomal Enzyme Trafficking Correction
Score: 0.71Lysosomal Calcium Channel Modulation Therapy
Score: 0.70Lysosomal Positioning Dynamics Modulation
Score: 0.69Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65Lysosomal Membrane Repair Enhancement
Score: 0.54Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54Blood-Brain Barrier SPM Shuttle System
Score: 0.53Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48...
Score: 0.68

Related Analyses (14)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedGene expression changes in aging mouse brain predicting neur
neurodegeneration · completedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (4)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Trehalose-induced lysosomal changes and TFEB activation
exploratory · proposed · Score: 0.90Trehalose-induced lysosomal membrane permeabilization and TF
exploratory · proposed · Score: 0.90Functional validation of trehalose effects on misfolded prot
exploratory · proposed · Score: 0.85

Knowledge Graph (12 edges)

FERROPTOSIS associated_with NEURONS
L-DOPA associated_with NEURONS
APP associated_with NEURONS
PINK1 associated_with NEURONS
PARKIN associated_with NEURONS
GDNF associated_with NEURONS
NEURONS associated_with FIBROBLASTS
APOE associated_with NEURONS
AMYGDALA associated_with NEURONS
NEURONS associated_with EPILEPSY

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