| Gene Symbol | CFB |
| Full Name | Complement Factor B |
| Protein Type | Protease |
| Function | Complement Factor B (CFB) is a serine protease that plays a critical role in the alternative pathway of the complement system. |
| Pathways | Alternative Complement Pathway, Glycolysis, Complement, Immune Response, Myelination |
| GeneCards | CFB |
| Human Protein Atlas | CFB |
| Multiple Sclerosis | CFB expression is elevated in demyelinating lesions [9] |
| Brain | CFB is expressed at low levels in healthy brain tissue, primarily by astrocytes and microglia |
| Regional Distribution | Higher expression in the hippocampus and cerebral cortex |
| Upregulation | Strongly induced during neuroinflammation and in neurodegenerative disease states |
| Cellular Localization | Secreted protein, localizes to blood-brain barrier and choroid plexus in brain |
| Associated Diseases | Als, Alzheimer |
| Interactions | CCL2, COMPLEMENT, Cytokine, CYTOKINES, GLAUCOMA, Hemoglobin |
| KG Connections | 92 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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