gene 1,002 words KG: STAT1 2026-03-24
kind:genesection:genesstate:published
Contents

STAT1 Gene - Signal Transducer and Activator of Transcription 1

🧬 Gene Info
Gene SymbolSTAT1
Full NameSignal Transducer and Activator of Transcription 1
AliasesPage for STAT1 Gene
Chromosome2q32.2
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight84 kDa
Pathwayscascade: ### Activation Mechanism, JAK-STAT signaling, JAK-STAT pathway
UniProt IDP42224
NCBI Gene ID6772
Ensembl IDENSG00000115415
GeneCardsSTAT1
Human Protein AtlasSTAT1
Associated DiseasesALS, Autoimmune, Depression, Infection, Inflammation
Known Drugs/Compoundsberberine, valproic acid, Curcumin, metformin
InteractionsSTAT3, TLR4, EGFR, JAK1, NRAS, ISG15
KG Connections882 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (27)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: activates
ASC (PYCARD)
gene · KG edge: expressed_in
AQP4 (Aquaporin-4 Gene)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

STAT1 associated_with STAT3
STAT1 activates STAT3
STAT1 activates TLR4
STAT1 activates EGFR
STAT1 regulates CSF2RA
STAT1 regulates S100A8
STAT1 activates JAK1
STAT1 activates NRAS
STAT1 associated_with USP18
STAT1 associated_with CXCL12