gene 1,002 words KG: STAT1
Contents

STAT1 Gene - Signal Transducer and Activator of Transcription 1

🧬 Gene Info
Gene SymbolSTAT1
Full NameSignal Transducer and Activator of Transcription 1
AliasesPage for STAT1 Gene
Chromosome2q32.2
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight84 kDa
Pathwayscascade: ### Activation Mechanism, JAK-STAT signaling, JAK-STAT pathway
UniProt IDP42224
NCBI Gene ID6772
Ensembl IDENSG00000115415
GeneCardsSTAT1
Human Protein AtlasSTAT1
Associated DiseasesAls, Autoimmune, Depression, Infection, Inflammation
Known Drugs/Compoundsberberine, Curcumin, metformin, valproic acid
InteractionsACE, AGING, AKT1, alpha-synuclein, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections858 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (27)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Aquaporin-4 Polarization Rescue
Score: 0.73
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
...
Score: 0.68
RNA Granule Nucleation Site Modulation
Score: 0.66
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Related Analyses (11)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

ANG — Angiogenin
gene · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
AKT1 Gene
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

STAT1 regulates INTERFERON_RESPONSE
JAK1 activates STAT1
STAT1 activates HIF1A
STAT1 activates ERRα
STAT1 activates STAT3
STAT1 activates TLR4
STAT1 activates EGFR
CSF2 regulates STAT1
NAMPT regulates STAT1
FGF2 regulates STAT1

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