| Gene Symbol | CHD4 |
| Full Name | Chromodomain Helicase DNA Binding Protein 4 |
| Chromosome | 12p12.3 |
| Function | CHD4 encodes a member of the chromodomain helicase family (CHD) that functions as an ATP-dependent chromatin remodeler. |
| Primary Expression | the central nervous system: |
| Molecular Weight | 226 kDa |
| UniProt ID | Q14839 |
| NCBI Gene ID | 2298 |
| Ensembl ID | ENSG00000124177 |
| OMIM | 605602 |
| GeneCards | CHD4 |
| Human Protein Atlas | CHD4 |
| Transcriptional repression | As part of NuRD complex, recruits HDAC1/2 to silence gene expression |
| Chromatin remodeling | Uses ATP hydrolysis to slide nucleosomes and regulate DNA accessibility |
| DNA damage response | Facilitates DNA repair by modulating chromatin structure |
| Associated Diseases | ALS, Migraine |
| Interactions | CHIP, KDM5A |
| KG Connections | 37 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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