disease

Migraine

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Migraine: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

238Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Migraine is a disease characterized by neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Aging, Als, Alzheimer. Connected to 123 entities in the SciDEX knowledge graph.

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Disease Info

HTR1A	Autoreceptor (somatodendritic) controlling firing rate
HTR1B	Autoreceptor (terminal) inhibiting release
HTR2A	Postsynaptic excitatory receptor
HTR2C	Postsynaptic receptor modulating pain and mood
HTR7	Postsynaptic excitatory receptor in circadian regulation
Associated Genes	OVERVIEW, MITOPHAGY, TNF, IL-6, TNF-Α, KCNK5, TGFB1, TP53
Therapeutic Agents	Niacin
KG Connections	204 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Migraine["Migraine"] -->|"associated"| Oxidative_Stress["Oxidative Stress"]
    Migraine["Migraine"] -->|"associated"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    Migraine["Migraine"] -->|"associated"| Huntington["Huntington"]
    Migraine["Migraine"] -->|"associated"| Inflammation["Inflammation"]
    Migraine["Migraine"] -->|"associated"| Ms["Ms"]
    Migraine["Migraine"] -->|"associated"| Autism["Autism"]
    Oxidative_stress["Oxidative stress"] -->|"causes"| Migraine["Migraine"]
    Cerebral_energy_deficiency["Cerebral energy deficiency"] -->|"causes"| Migraine["Migraine"]
    Cerebral_energy_metabolism["Cerebral energy metabolism"] -->|"associated"| Migraine["Migraine"]
    CCL3["CCL3"] -->|"activates"| Migraine["Migraine"]
    style Migraine fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (75)

Target	Relation	Type	Str
Inflammation	activates	disease	0.65
Oxidative Stress	associated_with	pathway	0.60
Blood-Brain Barrier	associated_with	pathway	0.60
Blood-Brain Barrier	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
Angiogenesis	activates	pathway	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Notch	contributes_to	pathway	0.60
Apoptosis	activates	pathway	0.60
Huntington	associated_with	disease	0.55
Inflammation	associated_with	disease	0.55
Ms	associated_with	disease	0.55
Autism	associated_with	disease	0.55
Parkinson	associated_with	disease	0.55
Multiple Sclerosis	associated_with	disease	0.55
Alzheimer	activates	disease	0.55
Neurodegeneration	activates	disease	0.55
Alzheimer	therapeutic_target	disease	0.55
Dementia	contributes_to	disease	0.55
Glaucoma	activates	disease	0.55
Circadian Rhythm	activates	pathway	0.55
Circadian Rhythm	therapeutic_target	pathway	0.55
Amyloid	activates	pathway	0.55
Inflammasome	activates	pathway	0.55
Neuroinflammatory	regulates	pathway	0.55
Cell Cycle	regulates	pathway	0.55
Ferroptosis	regulates	pathway	0.55
Calcium Signaling	regulates	pathway	0.55
Neuron	activates	cell_type	0.55
Microglia	activates	cell_type	0.55
Cholesterol	activates	pathway	0.55
Calcium Signaling	associated_with	pathway	0.55
Cell Cycle	associated_with	pathway	0.55
Macrophage	associated_with	cell_type	0.55
Neutrophil	associated_with	cell_type	0.55
Dendritic Cell	associated_with	cell_type	0.55
Astrocyte	regulates	cell_type	0.55
SCHIZOPHRENIA	associated_with	disease	0.50
ALZHEIMER	associated_with	gene	0.50
PARKINSON	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
HUNTINGTON	associated_with	gene	0.50
Parkinson's Disease	associated_with	disease	0.50
HUNTINGTON'S DISEASE	associated_with	concept	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
PARKINSON'S	associated_with	concept	0.50
HUNTINGTON'S	associated_with	concept	0.50
Pain	associated_with	disease	0.50

Incoming (163)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	0.75
Niacin	treats	drug	0.75
Oxidative stress	causes	process	0.70
Cerebral energy deficiency	causes	process	0.70
Cerebral energy metabolism	associated_with	process	0.70
CCL3	activates	gene	0.65
C1Q	activates	gene	0.65
CHR2	activates	gene	0.65
TNF	regulates	gene	0.65
OVERVIEW	associated_with	gene	0.65
GENES	activates	gene	0.65
MICROGLIA	regulates	gene	0.65
ASTROCYTES	regulates	gene	0.65
IL-6	regulates	gene	0.65
NEUROINFLAMMATION	interacts_with	gene	0.65
TNF-Α	regulates	gene	0.65
MITOPHAGY	associated_with	gene	0.65
FOS	activates	gene	0.65
C-FOS	activates	gene	0.65
SIRT1	regulates	gene	0.65
BMAL1	activates	gene	0.65
CIRCADIAN RHYTHM	activates	gene	0.65
TRPA1	inhibits	gene	0.65
SRC	regulates	gene	0.65
SCN8A	inhibits	gene	0.65
AKT1	inhibits	gene	0.65
TRPM3	inhibits	gene	0.65
CREBBP	inhibits	gene	0.65
CYTOKINES	regulates	gene	0.65
TNF	associated_with	gene	0.65
INFLAMMATION	regulates	gene	0.65
IL-6	associated_with	gene	0.65
NEUROINFLAMMATION	regulates	gene	0.65
TNF-Α	associated_with	gene	0.65
MICROGLIA	activates	gene	0.65
BDNF	activates	gene	0.65
TRKB	activates	gene	0.65
CX3CR1	activates	gene	0.65
KCNK5	associated_with	gene	0.65
TGFB1	associated_with	gene	0.65
TP53	associated_with	gene	0.65
NR1D1	associated_with	gene	0.65
FXN	associated_with	gene	0.65
EPHA5	associated_with	gene	0.65
EP300	associated_with	gene	0.65
NLGN2	associated_with	gene	0.65
CDK4	associated_with	gene	0.65
CHD4	associated_with	gene	0.65
HMGCR	associated_with	gene	0.65
TGFB3	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Migraine

Understanding Entity Pages

Summary

Wiki Pages (21)

Serotonergic Raphe Neurons in Migraine

Vascular Cognitive Impairment (VCI)

Spinal Cord Dorsal Horn Neurons

Growth Factor Therapeutics: Investment Landscape Analysis

Experiment Prioritization Index — Neurodegeneration

Multiple Sclerosis (MS)

Notch Signaling Pathway in Neurodegeneration

neurovascular-dysfunction

Kv7.2 Potassium Channel

HPA Axis Dysfunction in Neurodegeneration

Aurobindo Pharma Ltd.

Transcranial Direct Current Stimulation-Affected Neurons

Calcium Signaling Pathway in Neurodegeneration

Sleep Architecture Changes in CBS and PSP

Botulinum Toxin

Calcium Dysregulation to Excitotoxicity Pathway

Diseases

Pain in Corticobasal Syndrome

KCNAB3 — Potassium Voltage-Gated Channel Subfamily A Member Beta 3