gene 1,085 words KG: RPS6KB1 2026-03-24
kind:genesection:genesstate:published
Contents

RPS6KB1 Gene

🧬 Gene Info
Gene SymbolRPS6KB1
Chromosome17p13.3
Protein TypeSerine/Threonine Kinase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight70 kDa
Exons17
PathwaysmTOR, mtor
GeneCardsRPS6KB1
Human Protein AtlasRPS6KB1
IsoformFeatures
S6K1-p70Full-length, cytosolic
S6K1-p85Extended N-terminus
SiteKinase
Thr389mTORC1
Thr421/Ser424mTORC1
Associated DiseasesAD, ADH, AMI, Ischemia, Metabolic Syndrome, Ms
Known Drugs/Compoundsrapamycin
InteractionsGRB2, RHEB, STING1, EIF2A, LRRK2, ATG16L1
KG Connections551 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (16)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: interacts_with
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: interacts_with
ATF6 - Activating Transcription Factor 6
gene · KG edge: interacts_with
APC Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

RPS6KB1 activates RUBCN
RPS6KB1 activates SQSTM1
RPS6KB1 activates SREBF1
RPS6KB1 phosphorylates RPTOR
RPS6KB1 phosphorylates SQSTM1
RPS6KB1 phosphorylates STAT3
RPS6KB1 phosphorylates STING1
RPS6KB1 phosphorylates TFE3
RPS6KB1 phosphorylates TFEB
RPS6KB1 regulates RAB7A