gene 1,588 words KG: FXN
Contents

FXN — Frataxin

🧬 Gene Info
Gene SymbolFXN
Full NameFrataxin
Chromosome9q21.11
FunctionWithin this complex, frataxin
Primary ExpressionDorsal root ganglia, Spinal cord, Cerebellum, Heart, Pancreas, Liver
Molecular Weight14 kDa
Amino Acids210 aa
PathwaysAutophagy, Mitophagy
UniProt IDQ16595
Ensembl IDENSG00000165060
OMIM606829
GeneCardsFXN
Human Protein AtlasFXN
Symbol [@expression2024] FXN [@fox2019] [@delatycki2019] [@ncbi] Full Name [@omim] Frataxin [@proteins] [@httpswwwncbinlmnihgovgene] [@httpsensemblorghomosapiensgenesummarygensg] Chromosome [@httpsomimorgentry] 9q21.11 [@httpswwwuniprotorguniprotq] [@fxn] [@fxna] NCBI Gene [@httpswwwcurefaorg] 2395 EnsemblENSG00000165060
Associated DiseasesAtaxia, Friedreich's Ataxia, Migraine
InteractionsMITOCHONDRIA, C-MYC, AND, MYC, HMOX1, TFAM
KG Connections63 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.48
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48

Related Analyses (2)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Packard Center for ALS Research
institution · KG edge: therapeutic_target
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: therapeutic_target
FXN Gene (Frataxin)
gene · KG edge: causes
EPHA5 Gene
gene · KG edge: associated_with
EP300 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FXN associated_with EPHA5
FXN associated_with EP300
FXN associated_with NLGN2
FXN associated_with CDK4
FXN associated_with CHD4
FXN associated_with HMGCR
FXN associated_with TGFB3
FXN participates_in Iron Sulfur Cluster Biogenesis
FXN causes Friedreich's Ataxia
FXN associated_with GAA