concept

NIX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NIX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

673Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NIX is a concept in neurodegeneration research. Key relationships include: interacts with, regulates, associated with. Associated with AD, ALI, ALS. Connected to 312 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NIX
Key Genes/Proteins	ABCD3, ADORA2A, AGING, ALZHEIMER, ALZHEIMER DISEASE
Related Diseases	AD, Aging, ALI, Als, ALS
Related Pathways	Adaptive Immunity

Wiki Pages (1)

Knowledge base pages for this entity

BNIP3L — BCL2 Interacting Protein 3 Like (NIX)

gene · 738 words

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Pathway Diagram

graph TD
    NIX["NIX"]
    NIX -->|"regulates"| mitophagy["mitophagy"]
    NIX -->|"interacts"| Alzheimer["Alzheimer"]
    NIX -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    NIX -->|"interacts"| Dementia["Dementia"]
    NIX -->|"interacts"| Cardiovascular["Cardiovascular"]
    NIX -->|"interacts"| Parkinson["Parkinson"]
    NIX -->|"degrades"| Aging["Aging"]
    NIX -->|"activates"| ALS["ALS"]
    NIX -->|"regulates"| MITOPHAGY["MITOPHAGY"]
    AMPK["AMPK"] -->|"inhibits"| NIX
    HIF1["HIF1"] -->|"regulates"| NIX
    BCL2L11["BCL2L11"] -->|"interacts"| NIX
    DNA["DNA"] -->|"interacts"| NIX
    BNIP3["BNIP3"] -->|"contributes to"| NIX
    MITOPHAGY -->|"inhibits"| NIX

Outgoing (347)

Target	Relation	Type	Str
Mitophagy	regulates	pathway	1.00
Als	regulates	disease	0.95
programmed mitophagy	regulates	process	0.90
Programmed Mitophagy	mediates	process	0.90
programmed mitophagy	activates	process	0.90
Autophagy	regulates	pathway	0.90
Cancer	regulates	disease	0.85
oxidative stress response	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
AUTOPHAGY	regulates	gene	0.80
CANCER	regulates	gene	0.80
OVERVIEW	regulates	gene	0.80
PARKIN	regulates	gene	0.80
MITOCHONDRIA	regulates	gene	0.80
BNIP3L	regulates	gene	0.80
MITOCHONDRIA	associated_with	gene	0.80
Ischemia	regulates	disease	0.75
MITOPHAGY	regulates	pathway	0.74
UBIQUITIN	regulates	gene	0.70
BNIP3	regulates	gene	0.70
MITOCHONDRIA	activates	gene	0.70
apoptosis pathway	participates_in	pathway	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
mitophagy	regulates	process	0.70
neural stem cells	regulates	cell_type	0.70
PARKIN	associated_with	gene	0.70
Cardiovascular	degrades	disease	0.65
Ischemia	associated_with	disease	0.65
Aging	degrades	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
ALS	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Tumor	implicated_in	disease	0.65
Als	activates	disease	0.65
ALS	regulates	disease	0.65
Tumor	regulates	disease	0.65
Infection	activates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Cardiovascular	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Diabetes	therapeutic_target	disease	0.65

Incoming (326)

Source	Relation	Type	Str
MITOPHAGY	regulates	gene	1.00
BNIP3	regulates	gene	0.90
AMPK	inhibits	protein	0.82
P62	regulates	gene	0.80
HIF1	regulates	protein	0.74
BNIP3	associated_with	gene	0.70
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
AMPK	regulates	gene	0.70
PINK1	regulates	gene	0.70
OVERVIEW	regulates	gene	0.60
PARKIN	regulates	gene	0.60
CANCER	regulates	gene	0.60
HIF	activates	gene	0.60
JNK	activates	gene	0.60
MFN1	activates	gene	0.60
MIRO1	activates	gene	0.60
MUL1	activates	gene	0.60
ATG7	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
COX4I1	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
GFP	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
BNIP3L	degrades	gene	0.60
ATG7	protects_against	gene	0.60
BCL2	protects_against	gene	0.60
BCL2L13	protects_against	gene	0.60
BNIP3L	protects_against	gene	0.60
COX4I1	protects_against	gene	0.60
GAPDH	protects_against	gene	0.60
GFP	protects_against	gene	0.60
LC3B	protects_against	gene	0.60
MAP1LC3B	protects_against	gene	0.60
CNP	activates	gene	0.60
G6PD	activates	gene	0.60
GSR	activates	gene	0.60
HUWE1	activates	gene	0.60
NADPH	activates	gene	0.60
AND	activates	gene	0.60
AND	inhibits	gene	0.60
MITOPHAGY	inhibits	gene	0.60
ROS	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AMBRA1	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
BCL2L13	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NIX in their description or question text

No additional research found