gene 825 words KG: NDP52 2026-03-23
kind:genesection:genesstate:published
Contents

NDP52 Gene

🧬 Gene Info
Gene SymbolNDP52
Full NameNDP52
Chromosome21q22.12.
Protein TypeGene
FunctionMitophagy: NDP52 recognizes ubiquitinated damaged mitochondria and recruits LC3-positive autophagosomes through its LIR domain
Primary Expressionvarious tissues with particularly high expression in immune cells and neurons
Amino Acids452 aa
Exons11
PathwaysAdaptive Immunity, Autophagy, Complement, Immune Response, Innate Immunity
NCBI Gene IDSearch NCBI
GeneCardsNDP52
Human Protein AtlasNDP52
Associated DiseasesAD, ALI, ALS, AMI, Alzheimer
Known Drugs/Compoundsdimethyl fumarate, rapamycin, EGCG
InteractionsTAX1BP1, FUS, HIF1A, MAP1LC3B, GBA, FUNDC1
KG Connections1151 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (11)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Phase-Separated Organelle Targeting
Score: 0.52
Autophagosome Maturation Checkpoint Control
Score: 0.49
Stress Granule Phase Separation Modulators
Score: 0.49

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90
Autophagy receptor knockout effects on stress granule accumu
exploratory · proposed · Score: 0.85

See Also (6)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with
ACTB Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

NDP52 activates SQSTM1
NDP52 activates OPTINEURIN
NDP52 activates SMCR8
NDP52 activates TOLLIP
NDP52 activates PARL
NDP52 activates PERK
NDP52 activates PEX3
NDP52 activates PRKN
NDP52 activates PTEN
NDP52 activates RB1CC1