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Clinical: Davunetide (AL-108) PSP Trial
clinical
2,927 words
KG: PSP
2026-03-24
kind:clinical-trial
section:clinical-trials
state:published
Contents
Davunetide (AL-108) PSP Trial
Knowledge Graph
Related Hypotheses (26)
Aquaporin-4 Polarization Rescue
Score: 0.71
Microglial Purinergic Reprogramming
Score: 0.68
Complement C1q Subtype Switching
Score: 0.64
Sphingolipid Metabolism Reprogramming
Score: 0.64
Glial Glycocalyx Remodeling Therapy
Score: 0.62
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.62
Netrin-1 Gradient Restoration
Score: 0.57
APOE Isoform Conversion Therapy
Score: 0.69
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.80
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.77
Competitive APOE4 Domain Stabilization Peptides
Score: 0.76
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.74
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.74
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.73
APOE Isoform Expression Across Glial Subtypes
Score: 0.72
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.72
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.70
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.70
Lysosomal Enzyme Trafficking Correction
Score: 0.68
Lysosomal Calcium Channel Modulation Therapy
Score: 0.67
Lysosomal Membrane Repair Enhancement
Score: 0.66
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.66
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.64
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.61
Quantum Coherence Disruption in Cellular Communication
Score: 0.60
Show 21 more
Related Analyses (2)
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
Related Experiments (19)
4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40
Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Levodopa Response Determinants in PSP — Biomarker-Guided Pre
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40
Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Proteasome-Ubiquitin System Dysfunction Validation in Parkin
clinical · proposed · Score: 0.40
Protein Aggregation Kinetic Validation Results
validation · proposed · Score: 0.40
PSP and CBS Biomarker Validation Study
clinical · proposed · Score: 0.40
Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40
Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Tau Pathology Initiation Zone Identification
clinical · proposed · Score: 0.40
Tau Spreading Network Mapping via Spatial Transcriptomics in
clinical · proposed · Score: 0.40
Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40
Show 14 more
See Also (11)
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: expressed_in
Dementia Australia
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
DUSP10 Gene
gene · KG edge: associated_with
cdkn2a
gene · KG edge: associated_with
Genes
index · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: therapeutic_target
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Frontotemporal Dementia (FTD)
disease · KG edge: associated_with
Amyotrophic Lateral Sclerosis
redirect · KG edge: expressed_in
Show 6 more
Knowledge Graph (12 edges)
PSP
downregulates
SV2A
PSP
co_discussed
TAU
PSP
co_discussed
T CELL
PSP
co_discussed
SYNAPSE
PSP
co_discussed
STING
PSP
co_discussed
TBI
PSP
co_discussed
VCP
PSP
co_discussed
SLEEP
PSP
co_discussed
SMPD1
PSP
co_discussed
SQSTM1
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