Contents

DNAJB1 Gene

🧬 Gene Info

Gene Symbol	DNAJB1
Protein Type	Chaperone
Target Class	Chaperone
Function	DNAJB1 serves multiple essential cellular functions:
Mechanism of Action	Allosteric modulation of protein-protein interactions with Hsp70
Subcellular Localization	Cytosol: Predominant localization
Druggability	Low (0.35)
Clinical Stage	Phase I
Molecular Weight	38 kDa
Amino Acids	340 aa
Pathways	Chaperone, Complement, Lysosomal Degradation, Oxidative Stress
UniProt ID	M0QXK0
Ensembl ID	ENSG00000132002
GeneCards	DNAJB1
Human Protein Atlas	DNAJB1
Associated Diseases	Als, Alzheimer, Diabetes, Ms, neurodegeneration
Known Drugs/Compounds	115-7c, MAL3-101
Interactions	HSPA1A, HSP90AA1, FKBP5, UBIQUITIN, DNAJA1, HSP70
SciDEX Target	View Target Profile (5 clinical trials)
KG Connections	238 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Knowledge Graph