concept

FUT8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FUT8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

118Connections

0Hypotheses

1Analyses

50Outgoing

35Incoming

Summary

FUT8 is a concept in neurodegeneration research. Key relationships include: regulates, associated with, co discussed. Associated with ALS, Als, Arthritis. Connected to 57 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	FUT8
Key Genes/Proteins	EGFR, Tgfbr1, ST6GAL1
Related Diseases	Various Human Diseases, Arthritis, Als, Cancer
Related Pathways	N-glycosylation pathway

🔮 Predicted Structure: FUT8 — AlphaFold A0A669KAW1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FUT8["<b>FUT8</b>"]
    FUT8 -->|"mediates"| IgG_Core_Fucosylation["IgG Core Fucosylation"]
    FUT8 -->|"regulates"| Als["Als"]
    FUT8 -->|"regulates"| Cancer["Cancer"]
    FUT8 -->|"regulates"| Ms["Ms"]
    FUT8 -->|"activates"| Arthritis["Arthritis"]
    FUT8 -->|"transports"| ALS["ALS"]
    FUT8 -->|"expressed in"| ST6GAL1["ST6GAL1"]
    FUT8 -->|"regulates"| Tgf__["Tgf-Beta"]
    FUT8 -->|"regulates"| ERBB3["ERBB3"]
    h_9a108e26["h-9a108e26"] -->|"targets"| FUT8
    JUN["JUN"] -->|"regulates"| FUT8
    APP["APP"] -->|"regulates"| FUT8
    ST6GAL1 -->|"regulates"| FUT8
    MAX["MAX"] -->|"regulates"| FUT8
    EGFR["EGFR"] -->|"regulates"| FUT8
    BACE1["BACE1"] -->|"regulates"| FUT8
    ERBB3 -->|"regulates"| FUT8
    TCR["TCR"] -->|"regulates"| FUT8
    AND["AND"] -->|"regulates"| FUT8

Outgoing (83)

Target	Relation	Type	Str
N-glycosylation pathway	involved_in	pathway	0.95
Transferrin Glycosylation	regulates	process	0.90
Igg Glycosylation	regulates	process	0.90
α2,6-sialylation	suppresses	process	0.90
Glycoprotein Sialylation	regulates	process	0.85
EGFR	modulates	protein	0.85
Tgfbr1	modulates	protein	0.80
Various Human Diseases	associated_with	disease	0.70
ST6GAL1	co_mentioned_with	gene	0.70
Arthritis	activates	disease	0.65
Als	regulates	disease	0.65
Als	activates	disease	0.65
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
ALS	transports	disease	0.65
ALS	activates	disease	0.65
Als	transports	disease	0.65
ST6GAL1	expressed_in	gene	0.60
ST6GAL1	activates	gene	0.60
ST6GAL1	associated_with	gene	0.60
JUN	regulates	gene	0.60
MAX	associated_with	gene	0.60
ST6GAL1	regulates	gene	0.60
JUN	transports	gene	0.60
EGFR	regulates	gene	0.60
BACE1	regulates	gene	0.60
APP	regulates	gene	0.60
MAX	regulates	gene	0.60
neurodegeneration	implicated_in	disease	0.60
PI3K	regulates	gene	0.60
UBIQUITIN	activates	gene	0.60
AKT	regulates	gene	0.60
ST6GAL1	upregulates	entity	0.60
Transferrin	associated_with	protein	0.60
Rb	regulates	protein	0.60
Tgf-Β	regulates	pathway	0.60
ERBB3	regulates	gene	0.60
GENES	associated_with	gene	0.60
CANCER	regulates	gene	0.60
TRIM21	activates	gene	0.60
Pi3K/Akt	regulates	pathway	0.60
Neurogenesis	regulates	pathway	0.60
Differentiation	inhibits	pathway	0.60
Immune Response	regulates	pathway	0.60
AND	expressed_in	gene	0.60
AND	activates	gene	0.60
TCR	regulates	gene	0.60
Epithelial	regulates	cell_type	0.60
B Cell	activates	cell_type	0.60
Egfr	regulates	protein	0.60

Incoming (35)

Source	Relation	Type	Str
h-9a108e26	targets_gene	hypothesis	0.90
h-9a108e26	targets	hypothesis	0.80
JUN	regulates	gene	0.60
APP	regulates	gene	0.60
ST6GAL1	regulates	gene	0.60
MAX	regulates	gene	0.60
EGFR	regulates	gene	0.60
BACE1	regulates	gene	0.60
APP	associated_with	gene	0.60
BACE1	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
ST6GAL1	associated_with	gene	0.60
ST6GAL1	expressed_in	gene	0.60
ST6GAL1	activates	gene	0.60
JUN	transports	gene	0.60
FUT6	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
ERBB3	associated_with	gene	0.60
ERBB3	regulates	gene	0.60
TCR	regulates	gene	0.60
AND	regulates	gene	0.60
APOE4	activates	gene	0.55
APOE4	regulates	gene	0.55
APOE4	interacts_with	gene	0.55
APOE4	expressed_in	gene	0.55
B Cell	associated_with	cell_type	0.50
B Cell	activates	cell_type	0.50
TRANSFERRIN	interacts_with	protein	0.50
ST6GAL1	interacts_with	gene	0.43
APOE	co_discussed	gene	0.40
DNAJB1	co_discussed	gene	0.40
ST6GAL1	co_discussed	gene	0.40
HSPA1A	co_discussed	gene	0.40
HSP90AA1	co_discussed	gene	0.40
FKBP5	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

APOE4 structural biology and therapeutic targeting strategies

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.595

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FUT8

Understanding Entity Pages

Summary

Wiki Pages (5)

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