gene 1,299 words KG: DNAJB1 2026-03-22
kind:genesection:genesstate:published
Contents

DNAJB1 Gene

🧬 Gene Info
Gene SymbolDNAJB1
Protein TypeChaperone
Target ClassChaperone
FunctionDNAJB1 serves multiple essential cellular functions:
Mechanism of ActionAllosteric modulation of protein-protein interactions with Hsp70
Subcellular Localization**Cytosol**: Predominant localization
DruggabilityLow (0.35)
Clinical StagePhase I
Molecular Weight38 kDa
Amino Acids340 aa
PathwaysChaperone, Complement, Lysosomal Degradation, Oxidative Stress
UniProt IDM0QXK0
Ensembl IDENSG00000132002
GeneCardsDNAJB1
Human Protein AtlasDNAJB1
Associated DiseasesAls, Alzheimer, Diabetes, Ms, neurodegeneration
Known Drugs/Compounds115-7c, MAL3-101
InteractionsHSPA1A, HSP90AA1, FKBP5, UBIQUITIN, DNAJA1, HSP70
SciDEX TargetView Target Profile (5 clinical trials)
KG Connections238 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (22)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (10)

Can chaperone enhancement approaches overcome tau seed satur
protein folding · failed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (3)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 7 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 7 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 7 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 7 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 7 hypotheses

Knowledge Graph (12 edges)

DNAJB1 associated_with neurodegeneration
DNAJB1 interacts_with HSPA1A
DNAJB1 interacts_with HSP90AA1
DNAJB1 interacts_with FKBP5
DNAJB1 co_discussed ST6GAL1
DNAJB1 co_discussed FUT8
DNAJB1 co_discussed HSP90AA1
DNAJB1 co_discussed FKBP5
DNAJB1 expressed_in IKBKB
DNAJB1 expressed_in HSPA1B