Contents

GAP43 Gene

🧬 Gene Info

Gene Symbol	GAP43
Aliases	Neuromodulin
Chromosome	3q13.31
Protein Type	Structural Protein
Target Class	Structural Protein
Function	GAP43 (also known as neuromodulin) is a neuronal phosphoprotein specifically expressed in growing neurons during development and regeneration.
Mechanism of Action	Drugs targeting GAP43 would enhance axonal growth cone formation and synaptic plasticity by promoting phosphorylation or membrane translocation of GAP43, thereby facilitating neurite outgrowth and synapse formation. Alternatively, agents could upregulate GAP43 expression to restore neuronal connectivity and compensate for age-related decline in neurodegenerative conditions.
Primary Expression	growing ne
Druggability	Undruggable (0.21)
Clinical Stage	Approved
Molecular Weight	23.6 kDa
Pathways	Axonal Regeneration, Mitochondrial dynamics / bioenergetics
UniProt ID	P17642
NCBI Gene ID	2596
Ensembl ID	ENSG00000175676
GeneCards	GAP43
Human Protein Atlas	GAP43
Associated Diseases	ALS, Axon Degeneration, glioblastoma, neurodegeneration, ventricular arrhythmias
Known Drugs/Compounds	Pituitary Adenylyl Cyclase-Activating Peptide (PACAP), BDNF (Brain-Derived Neurotrophic Factor), Chondroitinase ABC, NSF127
Interactions	ACHE, Actin, AND, ANXIETY, APOPTOSIS, App
SciDEX Target	View Target Profile (5 clinical trials)
SciDEX Hypotheses	GAP43-mediated tunneling nanotube stabilization en
KG Connections	386 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph