gene

GLIOBLASTOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLIOBLASTOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2905Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

GLIOBLASTOMA is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 605 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GLIOBLASTOMA
Associated Diseases	Aging, Als, Alzheimer, Breast Cancer, Cancer
Known Drugs/Compounds	perampanel, TEMOZOLOMIDE
Interactions	Actin, ADSL, AGING, AKT, ALDH1A3, ALS
KG Connections	1390 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"associated"| MITOCHONDRIA["MITOCHONDRIA"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"associated"| Tumor["Tumor"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"associated"| Glioblastoma["Glioblastoma"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"activates"| Cancer["Cancer"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"expressed in"| Parkinson["Parkinson"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"expressed in"| Glioblastoma_1["Glioblastoma"]
    PI3K_AKT_MTOR_PATHWAY["PI3K_AKT_MTOR_PATHWAY"] -->|"activates"| GLIOBLASTOMA["GLIOBLASTOMA"]
    MTOR["MTOR"] -->|"activates"| GLIOBLASTOMA["GLIOBLASTOMA"]
    AUTOPHAGY["AUTOPHAGY"] -->|"co discussed"| GLIOBLASTOMA["GLIOBLASTOMA"]
    ALZHEIMER["ALZHEIMER"] -->|"co discussed"| GLIOBLASTOMA["GLIOBLASTOMA"]
    style GLIOBLASTOMA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1072)

Target	Relation	Type	Str
Glioblastoma	inhibits	disease	1.00
Glioma	activates	disease	1.00
Tumor	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Glioblastoma	therapeutic_target	disease	1.00
Glioblastoma	regulates	disease	1.00
Tumor	inhibits	disease	1.00
Tumor	activates	disease	1.00
Tumor	associated_with	disease	1.00
Als	activates	disease	1.00
Glioblastoma	activates	disease	1.00
Glioblastoma	associated_with	disease	1.00
Cancer	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
Glioma	associated_with	disease	1.00
immunosuppressive microenvironment	associated_with	phenotype	0.95
unfolded protein response	involves	pathway	0.90
neural stem cells	affects	cell_type	0.90
oxidative stress response	involves	pathway	0.90
PI3K-AKT-mTOR signaling	involves	pathway	0.90
Cranial Bone Marrow	associated_with	cell_type	0.90
macrophages	affects	cell_type	0.90
Brain Tumor	associated_with	disease	0.90
blood-brain barrier	involves	pathway	0.90
neurons	affects	cell_type	0.90
lipid metabolism	activates	process	0.90
blood-brain barrier	affects	brain_region	0.90
Autophagy	activates	pathway	0.90
Autophagy	activates	pathway	0.90
MTOR	activates	gene	0.90
Mtor	activates	pathway	0.90
Mtor	activates	pathway	0.90
Tumor Microenvironment	therapeutic_target	pathway	0.90
Glioma	therapeutic_target	disease	0.85
Tumor	treats	disease	0.85
Glioma	regulates	disease	0.85
Therapy Resistance	associated_with	phenotype	0.85
Circadian Rhythms	interacts_with	process	0.85
Cancer	inhibits	disease	0.85
Cancer	associated_with	disease	0.85
Als	regulates	disease	0.85
Als	associated_with	disease	0.85
Glioblastoma	treats	disease	0.85
Immune System	associated_with	process	0.80
Immunosuppression	associated_with	phenotype	0.80
lipid metabolism	involves	pathway	0.80
Metabolic Resistance	causes	phenotype	0.80
ubiquitin-proteasome	involves	pathway	0.80
astrocytes	affects	cell_type	0.80

Incoming (1833)

Source	Relation	Type	Str
CANCER	activates	gene	1.00
Tumor	activates	disease	1.00
NEURODEGENERATION	activates	gene	1.00
Cancer	activates	disease	1.00
Tumor	therapeutic_target	disease	1.00
Als	activates	disease	1.00
Als	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
GLIOBLASTOMA	inhibits	gene	1.00
GLIOBLASTOMA	associated_with	gene	1.00
GBM	therapeutic_target	gene	1.00
GLIOBLASTOMA	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	1.00
GLIOBLASTOMA	activates	gene	1.00
CANCER	activates	gene	1.00
Tumor	associated_with	disease	1.00
GBM	associated_with	gene	1.00
GBM	associated_with	gene	1.00
GBM	therapeutic_target	gene	1.00
EGFR	activates	gene	1.00
GLIOBLASTOMA	regulates	gene	1.00
CANCER	therapeutic_target	gene	1.00
EGFR	activates	gene	1.00
IDH1	associated_with	entity	0.98
PI3K	activates	gene	0.95
PI3K/Akt/mTOR	upregulates	pathway	0.95
Lipid Metabolism	promotes	pathway	0.95
GR	regulates	receptor	0.95
Glioblastoma Stem Cells	involved_in	cell_type	0.95
AUTOPHAGY	activates	gene	0.95
PI3K	therapeutic_target	gene	0.95
GBM	activates	gene	0.95
Neurodegeneration	activates	disease	0.95
AKT	therapeutic_target	gene	0.95
Glucocorticoids	modulates	compound	0.95
Glioma	associated_with	disease	0.95
Pi3K/Akt/Mtor	involved_in	pathway	0.95
Compound 1F	suppresses	compound	0.95
MTOR	activates	gene	0.95
Glioma	activates	disease	0.95
IDH2	associated_with	gene	0.92
Cranial Bone Marrow	associated_with	brain_region	0.90
MTOR	associated_with	gene	0.90
CYP46A1	regulates	gene	0.90
AKT	associated_with	gene	0.90
Lipid Metabolism	contributes_to	pathway	0.90
Lactate	contributes_to	compound	0.90
De Novo Lipid Synthesis	associated_with	process	0.90
GBM	regulates	gene	0.90
PI3K/AKT/MTOR	upregulates	pathway	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

neuro-oncology | 2026-04-13 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study demonstrates that high-neural glioblastoma cells form synapses with ne

closed · Rounds: 4 · Score: 0.62 · 2026-04-16

Related Research

Hypotheses and analyses mentioning GLIOBLASTOMA in their description or question text

No additional research found