disease

glioblastoma

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about glioblastoma: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2940Connections

0Hypotheses

1Analyses

37Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	EGFR, MET, RB1, PI3K, PDGFR, PTEN, CDK4, P16
Therapeutic Agents	temozolomide, RNA aptamer-DSPE conjugate, quercetin, reactive oxygen species, nanoplatform
KG Connections	460 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    glioblastoma["glioblastoma"] -->|"affects"| macrophages["macrophages"]
    style macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    glioblastoma["glioblastoma"] -->|"involves"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    glioblastoma["glioblastoma"] -->|"involves"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style PI3K_AKT_mTOR_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    glioblastoma["glioblastoma"] -->|"affects"| blood_brain_barrier["blood-brain barrier"]
    style blood_brain_barrier fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    glioblastoma["glioblastoma"] -->|"affects"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    glioblastoma["glioblastoma"] -->|"involves"| oxidative_stress_response["oxidative stress response"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    glioblastoma["glioblastoma"] -->|"involves"| lipid_metabolism["lipid metabolism"]
    style lipid_metabolism fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    STING["STING"] -->|"therapeutic target"| glioblastoma["glioblastoma"]
    style STING fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CAR_T_cells["CAR T cells"] -->|"treats"| glioblastoma["glioblastoma"]
    style CAR_T_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GBM["GBM"] -->|"treats"| glioblastoma["glioblastoma"]
    style GBM fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    STAT3["STAT3"] -->|"therapeutic target"| glioblastoma["glioblastoma"]
    style STAT3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TREM2["TREM2"] -->|"biomarker for"| glioblastoma["glioblastoma"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style glioblastoma fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (1061)

Target	Relation	Type	Str
immunosuppressive microenvironment	associated_with	phenotype	0.95
macrophages	affects	cell_type	0.90
unfolded protein response	involves	pathway	0.90
PI3K-AKT-mTOR signaling	involves	pathway	0.90
blood-brain barrier	affects	brain_region	0.90
neurons	affects	cell_type	0.90
oxidative stress response	involves	pathway	0.90
blood-brain barrier	involves	pathway	0.90
neural stem cells	affects	cell_type	0.90
lipid metabolism	involves	pathway	0.80
astrocytes	affects	cell_type	0.80
ubiquitin-proteasome	involves	pathway	0.80
ferroptosis	involves	pathway	0.70
brainstem	affects	brain_region	0.70
T cells	affects	cell_type	0.70
oligodendrocytes	affects	cell_type	0.70
microglia	affects	cell_type	0.70
cortex	affects	brain_region	0.70
NF-kB signaling	involves	pathway	0.70
Wnt signaling	involves	pathway	0.70
senescence	involves	pathway	0.70
AMPK signaling	involves	pathway	0.60
pericytes	affects	cell_type	0.60
TGF-beta signaling	involves	pathway	0.60
cholinergic neurons	affects	cell_type	0.60
epigenetic regulation	involves	pathway	0.60
mitochondrial dynamics	involves	pathway	0.60
autophagy pathway	involves	pathway	0.60
apoptosis pathway	involves	pathway	0.60
Notch signaling	involves	pathway	0.60
monocytes	affects	cell_type	0.60
B cells	affects	cell_type	0.60
NMDA receptor	involves	receptor	0.60
nitric oxide	disrupts	neurotransmitter	0.60
CRISPR-Cas	involves	pathway	0.60
pyroptosis	involves	pathway	0.60
glymphatic clearance	involves	pathway	0.60

Incoming (1879)

Source	Relation	Type	Str
STING	therapeutic_target	gene	0.90
CAR T cells	treats	cell_type	0.90
GBM	treats	gene	0.90
GBM	regulates	gene	0.90
GBM	associated_with	gene	0.90
GBM	implicated_in	gene	0.90
GBM	biomarker_for	gene	0.90
GBM	targets	gene	0.90
STAT3	therapeutic_target	protein	0.86
TREM2	biomarker_for	gene	0.85
EGFR	biomarker_for	protein	0.85
reactive oxygen species	treats	compound	0.85
nanoplatform	treats	compound	0.85
GBM	interacts_with	gene	0.80
RNA	expressed_in	gene	0.80
PI3K	promotes	gene	0.80
PI3K	regulates	gene	0.80
SLC16A1	regulates	gene	0.80
STING	activates	gene	0.80
MS4A6A	activates	gene	0.80
MTOR	associated_with	pathway	0.70
EGFR	associated_with	gene	0.70
temozolomide	treats	drug	0.70
MET	associated_with	gene	0.70
RB1	associated_with	gene	0.70
Wnt/β-catenin pathway	associated_with	pathway	0.70
PI3K/Akt/mTOR pathway	associated_with	pathway	0.70
NLGN3	activates	protein	0.70
RNA aptamer-DSPE conjugate	treats	drug	0.70
PI3K	associated_with	protein	0.70
PI3K/AKT/mTOR pathway	activates	pathway	0.70
hypoxia	activates	process	0.70
PDGFR	associated_with	protein	0.70
autophagy	associated_with	process	0.70
PAK1	activates	protein	0.70
miR-519a	protects_against	process	0.70
PTEN	associated_with	protein	0.70
CDK4	associated_with	gene	0.70
P16	associated_with	gene	0.70
glioma stem cells	activates	cell_type	0.70
epigenetic mechanisms	regulates	process	0.70
macrophages	activates	cell_type	0.70
microglia	activates	cell_type	0.70
STAT3	associated_with	protein	0.70
astrocytes	associated_with	cell_type	0.70
pRB	associated_with	protein	0.70
macrophage	activates	cell_type	0.70
TP53	associated_with	gene	0.70
IDH1	associated_with	gene	0.70
pRB	biomarker_for	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

neuro-oncology | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

glioblastoma

Understanding Entity Pages

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

CREB Signaling in Neurodegeneration

Exosome and Extracellular Vesicle Brain Delivery

bbb-transport-mechanisms

Exosome-Based Drug Delivery for CBS/PSP

Litronesib (LY317615/Enzastaurin)

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

RRAGB — Ras-Related GTP Binding B

PDCD10 Gene (Programmed Cell Death 10)

TERT Gene

TrkB Protein

slc22a1

Sirtuin Signaling Pathway

NanoCarrier Co., Ltd.

Megalencephalic Leukodystrophy

H3F3B Gene — H3.3 Histone B

FZD10 Gene

SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

NNMT Gene