gene 1,195 words KG: ALS10 2026-03-27
kind:genesection:genesstate:publishedtopic:alstopic:ftdtopic:rna-metabolism
Contents

ALS10 - Amyotrophic Lateral Sclerosis 10 (TARDBP)

🧬 Gene Info
Gene SymbolALS10
Full NameAmyotrophic Lateral Sclerosis 10 (TARDBP)
Chromosome1p36.22
Functionis a genetic locus associated with familial amyotrophic lateral sclerosis caused by mutations in the TARDBP gene (TAR DNA-Binding Protein).
Amino Acids414 aa
Gene TypeProtein coding
UniProt IDQ13148
NCBI Gene ID23435
Ensembl IDENSG00000120910
OMIM612069
GeneCardsALS10
Human Protein AtlasALS10
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Glaucoma
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45
Glycine-Rich Domain Competitive Inhibition
Score: 0.43
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.37

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (23)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
Environmental Exposure Causal Attribution in ALS — Experimen
validation · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
TARDBP — TAR DNA Binding Protein 43
gene · KG edge: associated_with
FIG4 — FIG4 Phosphatase Homolog
gene · KG edge: associated_with
Alsin (ALSIN)
gene · KG edge: associated_with
ALS9 - Amyotrophic Lateral Sclerosis 9
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ALS10 associated_with SOD1
ALS10 associated_with DNA
ALS10 associated_with AMYOTROPHIC LATERAL SCLEROSIS
ALS10 associated_with GENE MUTATIONS
ALS10 associated_with Als
ALS10 associated_with Glaucoma
ALS10 associated_with Amyotrophic Lateral Sclerosis
ALS10 data_in benchmark_ot_ad_answer_key:ALS10
ALS2 associated_with ALS10
FIG4 associated_with ALS10