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Home / Wiki / Entity: FUS Protein (Fused in Sarcoma)

entity 1,119 words KG: FUS 2026-03-22

kind:entity section:entities state:published

Contents

FUS Protein (Fused in Sarcoma)

Knowledge Graph

Related Hypotheses (30)

Cryptic Exon Silencing Restoration
Score: 0.46 Cross-Seeding Prevention Strategy
Score: 0.45 ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66 Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47 Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

SASP-Mediated Complement Cascade Amplification
Score: 0.70 Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68 Transcriptional Autophagy-Lysosome Coupling
Score: 0.66 Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59 Competitive APOE4 Domain Stabilization Peptides
Score: 0.56 APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54 Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53 Phase-Separated Organelle Targeting
Score: 0.52 Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52 GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52 Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51 Autophagosome Maturation Checkpoint Control
Score: 0.49 TREM2-mediated microglial tau clearance enhancement
Score: 0.49 RNA Granule Nucleation Site Modulation
Score: 0.48 APOE Isoform Expression Across Glial Subtypes
Score: 0.48 Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46 Lysosomal Membrane Repair Enhancement
Score: 0.45 Mitochondrial Transfer Pathway Enhancement
Score: 0.44 Glycine-Rich Domain Competitive Inhibition
Score: 0.43 Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42 VCP-Mediated Autophagy Enhancement
Score: 0.41 TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41 Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41 RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.37 Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (4)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40 ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40 Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40 TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (8)

Aducanumab (Aduhelm)
therapeutic · KG edge: activates Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed ADNP Gene
gene · KG edge: protects_against ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: activates ACTB Gene
gene · KG edge: activates

ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: inhibits ABCD3 Gene
gene · KG edge: interacts_with ABCA7 (Redirect)
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

FUS co_discussed LC3

FUS co_discussed P62

FUS co_discussed TARDBP

FUS co_discussed PROTEOSTASIS

FUS co_discussed TDP-43

FUS activates NBR1

FUS activates NDP52

FUS activates OPTINEURIN

FUS activates OPTN

FUS activates SMCR8

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