gene 1,321 words KG: ALS9 2026-03-27
kind:genesection:genesstate:published
Contents

ALS9 - Amyotrophic Lateral Sclerosis 9

🧬 Gene Info
Gene SymbolANG
AliasesGene profile: ANG, Angiogenin
Chromosome14q11.2
Protein TypeSecreted ribonuclease
Functionis a multifunctional protein that plays critical roles in both physiological and pathological processes within the nervous system.
Primary ExpressionBroad, high in liver, brain, and motor neurons
Molecular Weight14 kDa
Amino Acids147 aa
Exons2
PathwaysNF-κB
UniProt IDSearch UniProt
Ensembl IDENSG00000100939
OMIM105400
GeneCardsANG
Human Protein AtlasANG
Associated DiseasesCardiac, Heart Failure, Hypertension, Inflammation, Neuroinflammation
InteractionsKCNK2, NRP1, PIEZO1, PIEZO2, TNF, PDGFRB
KG Connections266 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.37
Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45
Glycine-Rich Domain Competitive Inhibition
Score: 0.43
Phase-Separated Organelle Targeting
Score: 0.52

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (26)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
TARDBP — TAR DNA Binding Protein 43
gene · KG edge: associated_with
FIG4 — FIG4 Phosphatase Homolog
gene · KG edge: associated_with
Alsin (ALSIN)
gene · KG edge: associated_with
ALS8 - Amyotrophic Lateral Sclerosis 8
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ALS9 associated_with TARDBP
ALS9 associated_with ALS7
ALS9 associated_with ALS10
ALS9 associated_with SOD1
ALS9 associated_with ALS
ALS9 associated_with GENES
ALS9 associated_with MOTOR NEURONS
ALS9 associated_with DNA
ALS9 associated_with AMYOTROPHIC LATERAL SCLEROSIS
ALS9 associated_with GENE MUTATIONS