gene 1,273 words KG: ALS8 2026-03-27
kind:genesection:genesstate:published
Contents

ALS8 - Amyotrophic Lateral Sclerosis 8

🧬 Gene Info
Gene SymbolVAPB
Full NameVesicle-Associated Membrane Protein-Associated Protein B
AliasesVAMP-Associated Protein B
Chromosome20q13.33
Protein TypeType III ER membrane protein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionUbiquitous, high in brain and spinal cord
Molecular Weight33 kDa
Amino Acids243 aa
PathwaysImmune Response
UniProt IDO95295
NCBI Gene ID9217
Ensembl IDENSG00000124194
OMIM607348
GeneCardsVAPB
Human Protein AtlasVAPB
Associated DiseasesAging, Als, Amyotrophic Lateral Sclerosis, Cardiovascular, Dementia, Ms
InteractionsVCP, NPC1, FUS, OPTN, UBQLN2, AND
KG Connections83 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.37
Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45
Glycine-Rich Domain Competitive Inhibition
Score: 0.43

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (26)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
TARDBP — TAR DNA Binding Protein 43
gene · KG edge: associated_with
FIG4 — FIG4 Phosphatase Homolog
gene · KG edge: associated_with
Alsin (ALSIN)
gene · KG edge: associated_with
ALS9 - Amyotrophic Lateral Sclerosis 9
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ALS8 associated_with ALSIN
ALS8 associated_with ALS4
ALS8 associated_with ALS9
ALS8 associated_with TARDBP
ALS8 associated_with ALS7
ALS8 associated_with ALS10
ALS8 associated_with SOD1
ALS8 associated_with ALS
ALS8 associated_with GENES
ALS8 associated_with MOTOR NEURONS