Contents

FIG4 — FIG4 Phosphatase Homolog

🧬 Gene Info

Gene Symbol	FIG4
Full Name	FIG4 Phosphatase Homolog
Protein Type	Phosphatase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	559 aa
Pathways	PI3K
Ensembl ID	ENSG00000112367
GeneCards	FIG4
Human Protein Atlas	FIG4
VAC14	scaffolds the PI(3,5)P2 synthesis complex with FIG4 and PIKFYVE
PIKFYVE	phosphorylates PI3P to generate PI(3,5)P2
FYCO1	interacts with PI3P for autophagosome-lysosome fusion
VPS34/PIK3C3	class III PI3K that produces PI3P
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Dementia, frontotemporal dementia, Ftd
Interactions	C9ORF72, C9ORF72 REPEAT EXPANSION
KG Connections	138 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph