gene 1,473 words KG: CAMK4 2026-03-26
kind:genesection:genesstate:published
Contents

CAMK4 — Calcium/Calmodulin-Dependent Kinase 4

🧬 Gene Info
Gene SymbolCAMK4
Full NameCalcium/Calmodulin-Dependent Kinase 4
AliasesGene page for CAMK4
Chromosome5q31.3
Protein TypeKinase
Functionis a serine/threonine protein kinase that plays a critical role in linking calcium signaling to gene transcription in neurons and immune cells.
Primary ExpressionHippocampus, Cerebellum, Thymus, Testis, T-lymphocytes
Subcellular Localizationthe postsynaptic density (PSD) and nucleus, with activity-dependent translocation between these compartments [4](https:/
Molecular Weight63 kDa
Amino Acids519 aa
Exons14
UniProt IDQ16566
NCBI Gene ID814
Ensembl IDENSG00000152495
OMIM114080
GeneCardsCAMK4
Human Protein AtlasCAMK4
Associated DiseasesCancer, Tumor
InteractionsGENES, ZBTB20, ANK3, ETV6, AND, CANCER
KG Connections31 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
LRP1-Dependent Tau Uptake Disruption
Score: 0.44

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (5)

SPP1 Gene
gene · KG edge: associated_with
CD8 Gene
gene · KG edge: associated_with
Genes
index · KG edge: activates
Tumor Necrosis Factor (TNF)
entity · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

CAMK4 expressed_in TEX
CAMK4 associated_with CD8
CAMK4 associated_with SPP1
CAMK4 therapeutic_target CD8
CAMK4 therapeutic_target SPP1
CAMK4 co_expressed_with CD8
CAMK4 co_expressed_with SPP1
CAMK4 associated_with Cancer
CAMK4 associated_with Tumor
CAMK4 activates GENES