gene 719 words KG: CD59
Contents

CD59 Gene

🧬 Gene Info
Gene SymbolCD59
Functionencodes a GPI-anchored cell surface glycoprotein that serves as a key complement regulatory protein.
Amino Acids171 aa
PathwaysComplement, Apoptosis, JAK-STAT signaling, NF-kB signaling
Ensembl IDENSG00000085059
GeneCardsCD59
Human Protein AtlasCD59
All nucleated cellsbroad constitutive expression
Neuronsparticularly in hippocampus and cortex
Associated DiseasesAlzheimer's disease
InteractionsAPOPTOSIS, BCL-2, C3, C4B, CD46, CD55
KG Connections23 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

Complement C1q Subtype Switching
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
...
Score: 0.68
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

See Also (9)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: activates
STAT3 (Redirect)
redirect · KG edge: activates
Tumor Necrosis Factor (TNF)
entity · KG edge: activates
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: activates

Knowledge Graph (12 edges)

FAS activates CD59
CD55 activates CD59
CD59 activates STAT3
CD55 regulates CD59
C4B activates CD59
CD46 regulates CD59
C3 inhibits CD59
CD46 inhibits CD59
CD55 inhibits CD59
CD46 activates CD59

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