Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CD46: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CD46 |
| Chromosome | 1q32.2 |
| Function | The CD46 gene encodes membrane cofactor protein (MCP), a crucial complement regulatory protein expressed on all nucleated cells |
| Pathways | complement cascade, JAK-STAT signaling, NF-kB signaling |
| Ensembl ID | ENSG00000108539 |
| GeneCards | CD46 |
| Human Protein Atlas | CD46 |
| Associated Diseases | neurodegeneration |
| Interactions | CD55, CD59, IDE, JAK2, STAT3, C3 |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["CD46"]
N1["C4B"]
N1 -->|"regulated by"| N0
N2["C3"]
N2 -->|"inhibits"| N0
N3["neurons"]
N0 -->|"expressed in"| N3
N4["CD55"]
N0 -->|"activates"| N4
N5["CD59"]
N0 -->|"regulates"| N5
N6["complement cascade"]
N0 -->|"participates in"| N6
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
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classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
class N0 gene
class N1 gene
class N2 gene
class N3 cell_type
class N4 gene
class N5 gene
class N6 pathway| Target | Relation | Type | Str |
|---|---|---|---|
| neurons | expressed_in | cell_type | 0.75 |
| CD55 | activates | gene | 0.65 |
| CD55 | regulates | gene | 0.65 |
| CD59 | regulates | gene | 0.65 |
| complement cascade | participates_in | pathway | 0.55 |
| CD55 | inhibits | gene | 0.55 |
| CD59 | inhibits | gene | 0.55 |
| CD59 | activates | gene | 0.55 |
| IDE | activates | gene | 0.55 |
| JAK2 | activates | gene | 0.55 |
| STAT3 | activates | gene | 0.55 |
| JAK-STAT signaling | participates_in | pathway | 0.55 |
| NF-kB signaling | participates_in | pathway | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||