gene

CD46

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD46: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
0Analyses
13Outgoing
2Incoming

Summary

Page for CD46

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🧬 Gene Info
Gene SymbolCD46
Chromosome1q32.2
FunctionThe CD46 gene encodes membrane cofactor protein (MCP), a crucial complement regulatory protein expressed on all nucleated cells
Pathwayscomplement cascade, JAK-STAT signaling, NF-kB signaling
Ensembl IDENSG00000108539
GeneCardsCD46
Human Protein AtlasCD46
Associated Diseasesneurodegeneration
InteractionsCD55, CD59, IDE, JAK2, STAT3, C3
KG Connections15 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

CD46

gene · 613 words

Complement System in Neurodegeneration

mechanism · 3221 words

Complement-Mediated Synapse Loss

mechanism · 3185 words

Complement System in Neurodegeneration

mechanism · 2480 words

C4B Gene

gene · 1977 words

CR3-Dependent Microglial Synapse Elimination in Parkinson's Disease

mechanism · 1931 words

Pathway Diagram

flowchart TD
    N0["CD46"]
    N1["C4B"]
    N1 -->|"regulated by"| N0
    N2["C3"]
    N2 -->|"inhibits"| N0
    N3["neurons"]
    N0 -->|"expressed in"| N3
    N4["CD55"]
    N0 -->|"activates"| N4
    N5["CD59"]
    N0 -->|"regulates"| N5
    N6["complement cascade"]
    N0 -->|"participates in"| N6

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    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
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    class N0 gene
    class N1 gene
    class N2 gene
    class N3 cell_type
    class N4 gene
    class N5 gene
    class N6 pathway

Outgoing (13)

TargetRelationTypeStr
neuronsexpressed_incell_type0.75
CD55activatesgene0.65
CD55regulatesgene0.65
CD59regulatesgene0.65
complement cascadeparticipates_inpathway0.55

Incoming (2)

SourceRelationTypeStr
C4Bregulated_bygene0.80
C3inhibitsgene0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found