gene 1,882 words KG: CERS1 2026-03-27
kind:genesection:genesstate:published
Contents

CERS1 — Ceramide Synthase 1

🧬 Gene Info
Gene SymbolCERS1 (LASS1)
Full NameCeramide Synthase 1 / Longevity Assurance 1
Chromosome19p13.3
Protein TypeEnzyme
Functionis a critical enzyme in the biosynthesis of ceramides, a fundamental class of sphingolipids essential for cellular membrane structure and signaling functions.
Molecular Weight~48 kDa
Amino Acids422 aa
PathwaysMitophagy
UniProt IDQ8IV08
NCBI Gene ID24145
Ensembl IDENSG00000154188
OMIM606919
FeatureDetails
Protein Length422 amino acids
ProductCarbon Length
Associated Diseasesneurodegeneration
InteractionsPINK1
KG Connections9 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
APOE-Dependent Autophagy Restoration
Score: 0.61
Ganglioside Rebalancing Therapy
Score: 0.50
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.47

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.46
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.46
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.46
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.46
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.46

See Also (8)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
PARKIN Gene
gene · KG edge: regulates
DRP1 Gene - Dynamin 1-Like Protein
gene · KG edge: regulates
Tumor Necrosis Factor (TNF)
entity · KG edge: regulates

Knowledge Graph (9 edges)

CERS1 regulates DRP1
CERS1 participates_in sphingolipid metabolism
CERS1 activates Als
CERS1 regulates Tumor
CERS1 activates Carcinoma
CERS1 activates Cancer
CERS1 regulates Mitophagy
PINK1 activates CERS1
PARKIN regulates CERS1