protein

COX15

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COX15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections
0Hypotheses
0Analyses
15Outgoing
6Incoming

Summary

Page for COX15 Protein

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🔬 Protein Info
Gene SymbolCOX15
Full NameCytochrome C Oxidase Assembly Factor 15
Chromosome10q24.2
FunctionCOX15 plays a crucial role in the final steps of heme A synthesis
Primary Expressionall tissues with high energy demands: - Heart and skeletal muscle (highest expression) - Brain (neurons and glia) - Liver and kid
Molecular Weight42 kDa
UniProt ID[Q7B433](https://www.uniprot.org/uniprot/Q7B433)
Ensembl IDENSG00000074981
OMIM603646
GeneCardsCOX15
Human Protein AtlasCOX15
Associated Diseasesneurodegeneration
InteractionsCOX4I1, COX7A1, COX8A, NDUFA12, NDUFA5, NDUFS1
KG Connections21 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

COX15 — Cytochrome C Oxidase Assembly Factor 15

gene · 786 words

COX20 Gene - Cytochrome c Oxidase Assembly Factor

gene · 3906 words

surf1

gene · 3165 words

COX14 — Cytochrome C Oxidase Assembly Factor 14

gene · 3101 words

SCO1 — Cytochrome c Oxidase Assembly Factor SCO1

gene · 3037 words

Mitochondrially Impaired Neurons

cell · 2673 words

Pathway Diagram

flowchart TD
    N0["COX15"]
    N1["ATP"]
    N0 -->|"activates"| N1
    N2["ACSL5"]
    N0 -->|"associated with"| N2
    N3["RPL4"]
    N0 -->|"associated with"| N3
    N4["Ras"]
    N0 -->|"activates"| N4
    N5["PPP1R7"]
    N5 -->|"associated with"| N0
    N6["ABCB1"]
    N6 -->|"associated with"| N0
    N7["PEX3"]
    N7 -->|"associated with"| N0
    N8["VPS33A"]
    N8 -->|"associated with"| N0
    N9["VPS16"]
    N9 -->|"associated with"| N0
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 protein
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene

Outgoing (15)

TargetRelationTypeStr
OXPHOSinvolved_inpathway0.90
Oxidative Phosphorylationinvolved_inpathway0.90
RPL4associated_withgene0.60
COX4I1inhibitsgene0.60
COX7A1inhibitsgene0.60

Incoming (6)

SourceRelationTypeStr
Chronic Tendon Injurydownregulatesdisease0.85
PPP1R7associated_withgene0.60
ABCB1associated_withgene0.60
PEX3associated_withgene0.60
VPS33Aassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found