gene 716 words KG: CRY2 2026-03-22
kind:genesection:genesstate:published
Contents

CRY2 Gene

🧬 Gene Info
Gene SymbolCRY2
Full NameCryptochrome Circadian Regulator 2
Chromosome4p16.3
FunctionThe CRY2 gene encodes Cryptochrome Circadian Regulator 2, a key component of the mammalian circadian clock.
Molecular Weight66 kDa
PathwaysAmyloid, Cholesterol, Circadian Rhythm, Lipid Metabolism, Mtor
UniProt IDQ96T44
NCBI Gene ID1399
Ensembl IDENSG00000116771
OMIM604961
GeneCardsCRY2
Human Protein AtlasCRY2
Photolyase homology region (PHR)the FAD-binding domain
Tail domaininvolved in protein interactions
DAS motifdouble Asp residues for FAD binding
Associated DiseasesAls, Depression, Stroke
InteractionsHDAC3, PER1, PER2, AMYLOID, ALZHEIMER, INS
KG Connections112 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
HDAC3-Selective Inhibition for Clock Reset
Score: 0.46
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (9)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

Circadian gene expression effects of SD vs ketamine
exploratory · proposed · Score: 0.95
CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: expressed_in
CRY1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CRY2 regulates CLOCK
CRY2 associated_with BMAL1
CRY2 expressed_in PER2
CRY2 expressed_in SIRT1
CRY2 expressed_in CLOCK
CRY2 associated_with PER2
CRY2 associated_with CLOCK
CRY2 regulates PER2
CRY2 regulates BMAL1
CRY2 expressed_in CRY1