gene 744 words KG: PER2 2026-03-24
kind:genesection:genesstate:published
Contents

PER2 Gene

🧬 Gene Info
Gene SymbolPER2
Chromosome2p13
FunctionPER2 is a core clock gene essential for circadian rhythm generation.
Molecular Weight180 kDa
PathwaysAkt, Circadian Rhythm, Lipid Metabolism, Mtor, Pi3K
UniProt IDQ8BZD0
NCBI Gene ID8864
Ensembl IDENSG00000132266
OMIM603714
GeneCardsPER2
Human Protein AtlasPER2
Gene NamePeriod Circadian Regulator 2
CategoriesCircadian Rhythm, Transcriptional Regulation, Sleep Biology
Associated DiseasesALS, Ms, autism spectrum disorder
InteractionsCLOCK, BMAL1, NR1D1, HSP70, ATF3, DLAT
KG Connections202 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Circadian-Metabolic Microglial Reprogramming
Score: 0.46
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62

Related Analyses (11)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (4)

Circadian gene expression effects of SD vs ketamine
exploratory · proposed · Score: 0.95
CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: expressed_in
BDNF Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

PER2 expressed_in CLOCK
PER2 expressed_in BMAL1
PER2 activates CLOCK
PER2 activates BMAL1
PER2 regulates SIRT1
PER2 regulates CLOCK
PER2 regulates BMAL1
PER2 regulates ARNT
PER2 inhibits CLOCK
PER2 expressed_in LPL