gene 879 words KG: CRY1 2026-03-22
kind:genesection:genesstate:published
Contents

CRY1 Gene

🧬 Gene Info
Gene SymbolCRY1
Full NameCryptochrome Circadian Regulator 1
Chromosome12q24.31
FunctionTranscriptional Activation: CLOCK and BMAL1 proteins form a heterodimer that activates transcription of period (PER) and cryptochrome (CRY) genes
Primary ExpressionUbiquitous (high in brain, liver, retina)
Molecular Weight66 kDa
Amino Acids500 aa
PathwaysAkt, Circadian Rhythm, Lipid Metabolism, Mtor, Nf-Κb
UniProt IDQ9UQL6
NCBI Gene ID1399
Ensembl IDENSG00000012048
OMIM601033
GeneCardsCRY1
Human Protein AtlasCRY1
Associated DiseasesAls, Depression, Stroke
InteractionsTNFRSF1A, ICAM1, BMAL1, CLOCK, PER1, PER2
KG Connections219 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (19)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61

Related Analyses (10)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (2)

Circadian gene expression effects of SD vs ketamine
exploratory · proposed · Score: 0.95
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40

See Also (8)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: expressed_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: expressed_in
BMAL1 (ARNTL) Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CRY1 regulates BMAL1
CRY1 regulates ARNT
CRY1 regulates TNF
CRY1 activates TNFRSF1A
CRY1 regulates OCLN
CRY1 activates ICAM1
CRY1 contributes_to ICAM1
CRY1 contributes_to TNFRSF1A
CRY1 interacts_with BMAL1
CRY1 interacts_with CLOCK