gene 676 words KG: BECN1 2026-03-22
kind:genesection:genesstate:published
Contents

BECN1 Gene

🧬 Gene Info
Gene SymbolBECN1
Full NameBeclin-1
Chromosome17q21.31
FunctionBECN1 encodes beclin-1, a key regulator of autophagy—a cellular process for degrading and recycling damaged organelles, protein aggregates, and intracellular pathogens.
Molecular Weight60 kDa
PathwaysAkt, Apoptosis, Autophagy, Car-T, Epigenetic
UniProt IDQ9Y5P6
NCBI Gene ID9451
Ensembl IDENSG00000126581
OMIM604378
GeneCardsBECN1
Human Protein AtlasBECN1
CompoundStatus
RapamycinFDA approved (organ transplant)
MetforminFDA approved (diabetes)
Associated DiseasesAD, ALI, ALS, AMI, Alzheimer
Known Drugs/CompoundsRAPAMYCIN, SORAFENIB, rapamycin, nicotine, crocin, HCQ
InteractionsC9ORF72, NBR1, G3BP1, TOLLIP, SQSTM1, NDP52
KG Connections2944 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Circadian Clock-Autophagy Synchronization
Score: 0.55
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67

Related Analyses (18)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
AKT1 Gene
gene · KG edge: interacts_with
AIF1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

BECN1 associated_with PINK1
BECN1 associated_with STAT3
BECN1 co_discussed CGAS
BECN1 co_discussed JNK
BECN1 co_discussed P62
BECN1 co_discussed CLDN5
BECN1 co_discussed HIF1A
BECN1 co_discussed LC3
BECN1 upregulates LC3
BECN1 regulates TAU