| Gene Symbol | AMBRA1 |
| Aliases | AMBRA1, KIAA1731 |
| Chromosome | 11p15.5 |
| Protein Family | WD40 repeat-containing proteins |
| Function | encodes a critical positive regulator of autophagy that plays essential roles in cellular homeostasis, development, and disease pathogenesis[@cecconi2008][@fimia2012]. |
| Gene Type | Protein-coding |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Immune Response |
| UniProt ID | Q9C0A1 |
| NCBI Gene ID | 55626 |
| Ensembl ID | ENSG00000164024 |
| GeneCards | AMBRA1 |
| Human Protein Atlas | AMBRA1 |
| Gene Name | Activating Molecule in Beclin 1-Regulated Autophagy 1 |
| Approach | Model |
| AAV-AMBRA1 | PD model |
| Associated Diseases | AD, ALI, ALS, ALZHEIMER'S DISEASE, Age-Related Macular Degeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | PINK1, BCL2L13, NLRP3, ABCD3, FIP200, RTN3 |
| KG Connections | 1112 knowledge graph edges |
| Databases | GeneCardsHPASTRING |