gene 2,089 words KG: HDAC10 2026-03-28
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsonstopic:epigeneticstopic:autophagy
Contents

HDAC10 Gene

🧬 Gene Info
Gene SymbolHDAC10
Full NameHDAC10
AliasesHistone Deacetylase 10
Chromosome22q13.33.
Protein TypeGene
Functionis a class IIb histone deacetylase encoded by the HDAC10 gene located on chromosome 22q13.
Primary Expressionboth neurons and glia, with astrocytic and microglial expression particularly relevant to understanding its role in neuroinflammation
Subcellular Localizationand function
Molecular Weight78 kDa
Amino Acids669 aa
Exons16
PathwaysEpigenetic
NCBI Gene IDSearch NCBI
GeneCardsHDAC10
Human Protein AtlasHDAC10
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsHDAC1, DNMT3A, AND
KG Connections15 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (7)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (9)

Packard Center for ALS Research
institution · KG edge: therapeutic_target
VEGF (Vascular Endothelial Growth Factor)
gene · KG edge: therapeutic_target
HDAC1 Gene
gene · KG edge: activates
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: therapeutic_target
EGF Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

HDAC10 activates HDAC1
HDAC10 activates DNMT3A
HDAC10 therapeutic_target VEGF
HDAC10 therapeutic_target EGF
HDAC10 therapeutic_target EGFR
HDAC10 therapeutic_target CANCER
HDAC10 therapeutic_target Als
HDAC10 therapeutic_target Carcinoma
HDAC10 therapeutic_target Cancer
HDAC10 activates Tumor