concept

CAMKII

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAMKII: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

149Connections

1Hypotheses

0Analyses

50Outgoing

41Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CAMKII
Related Diseases	Als, Depression
Linked Hypotheses	1 hypotheses

🧬 3D Structure: CAMKII — PDB 3SOA Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CAMKII["CAMKII"]
    style CAMKII fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CAMKII -->|"activates"| HEPATIC_MITOCHONDRIAL_OXIDATIO["HEPATIC MITOCHONDRIAL OXIDATION"]
    CAMKII -->|"expressed in"| Pyramidal_Neurons["/Pyramidal Neurons/"]
    CAMKII -->|"regulates"| Hepatic_Mitochondrial_Oxidatio["Hepatic Mitochondrial Oxidation"]
    CAMKII -->|"regulates"| Intrahepatic_Lipolysis["Intrahepatic Lipolysis"]
    CAMKII -->|"regulates"| Gluconeogenesis["Gluconeogenesis"]
    CAMKII -->|"activates"| INTRAHEPATIC_LIPOLYSIS["INTRAHEPATIC LIPOLYSIS"]
    CAMKII -->|"regulates"| GLUCONEOGENESIS["GLUCONEOGENESIS"]
    CAMKII -->|"phosphorylates"| SAP97([SAP97])
    CAMKII -->|"regulates"| mitochondrial_oxidation["mitochondrial oxidation"]
    Cytosolic_Calcium["Cytosolic Calcium"] -->|"activates"| CAMKII
    CYTOSOLIC_CALCIUM["CYTOSOLIC CALCIUM"] -->|"activates"| CAMKII
    GluN2B([GluN2B]) -->|"activates"| CAMKII
    DLAT([DLAT]) -->|"regulates"| CAMKII
    AMPK([AMPK]) -->|"activates"| CAMKII
    FOXO1([FOXO1]) -->|"activates"| CAMKII
    FOXO4([FOXO4]) -->|"activates"| CAMKII
    AXON([AXON]) -->|"regulates"| CAMKII
    NEURON([NEURON]) -.->|"inhibits"| CAMKII

Outgoing (106)

Target	Relation	Type	Str
HEPATIC MITOCHONDRIAL OXIDATION	activates	entity	0.95
Pyramidal Neurons	expressed_in	cell_type	0.95
Hepatic Mitochondrial Oxidation	regulates	process	0.90
Intrahepatic Lipolysis	regulates	process	0.90
Gluconeogenesis	regulates	process	0.90
INTRAHEPATIC LIPOLYSIS	activates	entity	0.90
GLUCONEOGENESIS	regulates	entity	0.85
hepatic mitochondrial oxidation	mediates	process	0.80
intrahepatic lipolysis	mediates	process	0.80
gluconeogenesis	mediates	process	0.80
Als	activates	disease	0.65
Als	regulates	disease	0.65
Depression	activates	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Stroke	activates	disease	0.65
Senescence	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
ALS	activates	disease	0.65
Heart Failure	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Ischemia	associated_with	disease	0.65
Addiction	regulates	disease	0.65
Als	inhibits	disease	0.65
MCU	activates	gene	0.60
AKT	activates	gene	0.60
Autophagy	activates	pathway	0.60
Ubiquitin-Proteasome	activates	pathway	0.60
Stem Cell	activates	cell_type	0.60
CALCINEURIN	regulates	gene	0.60
Neuron	inhibits	cell_type	0.60
BDNF	activates	gene	0.60
CHR2	activates	gene	0.60
Mtor	activates	pathway	0.60
Neuron	activates	cell_type	0.60
TRKB	inhibits	gene	0.60
Mitochondrial Function	activates	pathway	0.60
AKT	associated_with	gene	0.60
MAP2	activates	gene	0.60
TRKB	associated_with	gene	0.60
Epigenetic	activates	pathway	0.60
Neuron	associated_with	cell_type	0.60
AND	activates	gene	0.60
AQP1	transports	gene	0.60
AND	inhibits	gene	0.60
MEF2A	inhibits	gene	0.60
AGING	inhibits	gene	0.60
Epigenetic	inhibits	pathway	0.60
Angiogenesis	inhibits	pathway	0.60

Incoming (43)

Source	Relation	Type	Str
Cytosolic Calcium	activates	compound	0.95
CYTOSOLIC CALCIUM	activates	entity	0.95
AMPK	activates	gene	0.60
FOXO1	activates	gene	0.60
FOXO4	activates	gene	0.60
AXON	regulates	gene	0.60
AMPK	regulates	gene	0.60
NEURON	inhibits	gene	0.60
EXERCISE	regulates	gene	0.60
DEPRESSION	activates	gene	0.60
MTOR	activates	gene	0.60
EEF2	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
IL-1	activates	gene	0.60
AEP	inhibits	gene	0.60
ERK	associated_with	gene	0.60
HDAC	activates	gene	0.60
CREB	associated_with	gene	0.60
HDAC2	activates	gene	0.60
CHR2	activates	gene	0.60
JUN	activates	gene	0.60
NEURON	activates	gene	0.60
STROKE	activates	gene	0.60
BDNF	activates	gene	0.60
DNA	inhibits	gene	0.60
AMPK	transports	gene	0.60
HDAC4	inhibits	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
PINK1	associated_with	gene	0.60
ERK1	associated_with	gene	0.60
PARK2	associated_with	gene	0.60
ERK1/2	associated_with	gene	0.60
MCU	activates	gene	0.60
AKT	activates	gene	0.60
MAP2	activates	gene	0.60
AKT	associated_with	gene	0.60
FOXO	activates	gene	0.60
TNF	inhibits	gene	0.60
IL3	inhibits	gene	0.60
IL1B	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CaMKII-Dependent Synaptic Circuit Amplification	0.444	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Chaperone-mediated autophagy as a sex-specific modulator of synaptic proteostasi [PMID:41358563]	Luo R	Autophagy	2026
The mPFC molecular clock mediates the effects of sleep deprivation on depression [PMID:41023421]	Gardner W, Sarrazin DH, Balzinger M, Mar	Mol Psychiatry	2026
Sexually dimorphic cannabinoid 1 receptors on CaMKIIα neurons in the medial pref [PMID:41380094]	Wang Q, Zhao J, Zhang X, Huang C, Li Y e	Pain	2026
A bioinspired anisotropic anti-inflammatory scaffold enhances spinal nerve regen [PMID:41737465]	Jiang M, Lu W, Zhuang J, Song J, Zhao Y	Mater Today Bio	2026
A multi-omics comparison unveils convergent and divergent antidepressant mechani [PMID:41796893]	Zhang J, Cai Y, Zhang P, Hao X, Guo B et	J Proteomics	2026

CAMKII

Understanding Entity Pages

Wiki Pages (20)

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ncam2

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dendritic-spines

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NPAS3 Gene

Ion Channel Dysfunction in Huntington's Disease

CALM4 — Calmodulin 4

Calcium Signaling Dysregulation in Neurodegeneration

Synaptic Plasticity Deficits in Neurodegeneration

SLC30A3 — Solute Carrier Family 30 Member 3 (ZnT3)

tau-hyperphosphorylation

JPH2 — Junctophilin 2

iron-calcium-glymphatic-convergence-alzheimers

TGF-β Signaling in Parkinson's Disease