protein

CCND1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCND1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

401Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for CCND1 Protein (Cyclin D1)

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🔬 Protein Info

Gene Symbol	CCND1
Aliases	Cyclin D1
Primary Expression	Hippocampus
Molecular Weight	34 kDa
Amino Acids	100 aa
Pathways	Autophagy, Wnt, Mtor, Nf-Κb, Pi3K/Akt
GeneCards	CCND1
Human Protein Atlas	CCND1
Associated Diseases	ALS, Cancer, Carcinoma
Known Drugs/Compounds	rapamycin
Interactions	GENES, AKT, BCL2L1, NF-ΚB, IL1B, AND
KG Connections	401 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CCND1(["CCND1"])
    chromothripsis["chromothripsis"]
    MYC["MYC"]
    Tumor["Tumor"]
    Cancer["Cancer"]
    ALS["ALS"]
    Carcinoma["Carcinoma"]
    Als["Als"]
    Alzheimer["Alzheimer"]
    Diabetes["Diabetes"]
    Fibrosis["Fibrosis"]
    Glioblastoma["Glioblastoma"]
    ATG["ATG"]
    TCF4["TCF4"]
    TSPAN1["TSPAN1"]
    AXIN["AXIN"]
    chromothripsis -->|"upstream_of"| CCND1
    MYC -->|"coexpressed_wit"| CCND1
    CCND1 -->|"activates"| Tumor
    CCND1 -.-|"associated"| Cancer
    CCND1 -->|"activates"| ALS
    CCND1 -.-|"associated"| Carcinoma
    CCND1 -->|"expressed in"| ALS
    CCND1 -->|"expressed in"| Carcinoma
    CCND1 -->|"activates"| Als
    CCND1 -->|"expressed in"| Als
    CCND1 -->|"regulates"| Alzheimer
    CCND1 -.->|"inhibits"| Diabetes
    CCND1 -.->|"inhibits"| Fibrosis
    CCND1 -->|"activates"| Cancer
    CCND1 -->|"activates"| Glioblastoma
    CCND1 -.-|"associated"| MYC
    CCND1 -.-|"associated"| ATG
    CCND1 -.-|"associated"| TCF4
    CCND1 -.-|"associated"| TSPAN1
    CCND1 -.-|"associated"| AXIN
    style CCND1 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (264)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.70
Tumor	activates	disease	0.65
Cancer	associated_with	disease	0.65
ALS	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Als	activates	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Diabetes	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Cancer	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Cardiovascular	inhibits	disease	0.65
Cardiomyopathy	inhibits	disease	0.65
Als	inhibits	disease	0.65
MYC	associated_with	gene	0.60
ATG	associated_with	gene	0.60
TCF4	associated_with	gene	0.60
TSPAN1	associated_with	gene	0.60
AXIN	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
MIR454	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
GENES	activates	gene	0.60
AKT	activates	gene	0.60
EGFR MUTATIONS	expressed_in	gene	0.60
BCL2L1	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
NF-ΚB	activates	gene	0.60
IL1B	activates	gene	0.60
EGFR	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
ELF3	activates	gene	0.60
PI3K	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Cell Cycle	expressed_in	pathway	0.60
Apoptosis	activates	pathway	0.60
Glycolysis	expressed_in	pathway	0.60
AXIN2	associated_with	gene	0.60
FAM83A	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
GFP	associated_with	gene	0.60

Incoming (137)

Source	Relation	Type	Str
chromothripsis	upstream_of	process	0.80
MYC	coexpressed_with	gene	0.76
LAMP1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
WNT	associated_with	gene	0.60
RAS	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
APC	associated_with	gene	0.60
CSNK1A1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
GFP	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
AXIN2	associated_with	gene	0.60
RNA	associated_with	gene	0.60
CYCLIN D1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
CTNNB1	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
FAM83A	associated_with	gene	0.60
AND	activates	gene	0.60
P62	activates	gene	0.60
CANCER	associated_with	gene	0.60
MIR454	associated_with	gene	0.60
ATG	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
IL1B	activates	gene	0.60
BCL2L1	activates	gene	0.60
RNA	expressed_in	gene	0.60
TXNIP	activates	gene	0.60
SOCS3	activates	gene	0.60
MICRORNAS	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
YWHAZ	activates	gene	0.60
MYC	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MYH9	activates	gene	0.60
STAT3	activates	gene	0.60
EGR1	activates	gene	0.60
TBP	activates	gene	0.60
RELA	activates	gene	0.60
MMP2	associated_with	gene	0.60
ERK	inhibits	gene	0.60
ROS	inhibits	gene	0.60
NOX4	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
SLC2A1	associated_with	gene	0.60
CYP1A1	associated_with	gene	0.60
PPP5C	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CCND1

Understanding Entity Pages

Summary

Wiki Pages (20)

FOXO1 Protein

WNT7A Gene

GLI1 — GLI Family Zinc Finger 1

Hedgehog Signaling in Neurodegeneration

DVL3 — Dishevelled Segment Polarity Protein 3

Cyclin E2 (CCNE2) Protein

FZD8 Gene

FZD8 Protein

GLI Gene Family

WNT3 Gene

SHH — Sonic Hedgehog

CHD8 Gene

beta-catenin-protein

LATS1 — Large Tumor Suppressor Kinase 1, Hippo Pathway

SMO — Smoothened, Frizzled Class Receptor

FZD9 Protein

TBP - TATA-Box Binding Protein

GLI2