protein

CCND1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCND1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

397Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for CCND1 Protein (Cyclin D1)

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	CCND1
Aliases	Cyclin D1
Primary Expression	Hippocampus
Molecular Weight	34 kDa
Amino Acids	100 aa
Pathways	Autophagy, Wnt, Mtor, Nf-Κb, Pi3K/Akt
GeneCards	CCND1
Human Protein Atlas	CCND1
Associated Diseases	ALS, Cancer, Carcinoma
Known Drugs/Compounds	rapamycin
Interactions	AKT, AMPK, APC, APOPTOSIS, ATG, AXIN1
KG Connections	397 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

CCND1 Protein (Cyclin D1)

protein · 554 words

→

Pathway Diagram

graph TD
    CCND1(["CCND1"])
    chromothripsis["chromothripsis"]
    MYC["MYC"]
    Tumor["Tumor"]
    Cancer["Cancer"]
    ALS["ALS"]
    Carcinoma["Carcinoma"]
    Als["Als"]
    Alzheimer["Alzheimer"]
    Diabetes["Diabetes"]
    Fibrosis["Fibrosis"]
    Glioblastoma["Glioblastoma"]
    ATG["ATG"]
    TCF4["TCF4"]
    TSPAN1["TSPAN1"]
    AXIN["AXIN"]
    chromothripsis -->|"upstream_of"| CCND1
    MYC -->|"coexpressed_wit"| CCND1
    CCND1 -->|"activates"| Tumor
    CCND1 -.-|"associated"| Cancer
    CCND1 -->|"activates"| ALS
    CCND1 -.-|"associated"| Carcinoma
    CCND1 -->|"expressed in"| ALS
    CCND1 -->|"expressed in"| Carcinoma
    CCND1 -->|"activates"| Als
    CCND1 -->|"expressed in"| Als
    CCND1 -->|"regulates"| Alzheimer
    CCND1 -.->|"inhibits"| Diabetes
    CCND1 -.->|"inhibits"| Fibrosis
    CCND1 -->|"activates"| Cancer
    CCND1 -->|"activates"| Glioblastoma
    CCND1 -.-|"associated"| MYC
    CCND1 -.-|"associated"| ATG
    CCND1 -.-|"associated"| TCF4
    CCND1 -.-|"associated"| TSPAN1
    CCND1 -.-|"associated"| AXIN
    style CCND1 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (262)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.70
Cardiomyopathy	inhibits	disease	0.65
Carcinoma	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Als	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	activates	disease	0.65
Cancer	associated_with	disease	0.65
ALS	activates	disease	0.65
Als	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Cardiovascular	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Fibrosis	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Als	inhibits	disease	0.65
Apoptosis	inhibits	pathway	0.60
GENES	regulates	gene	0.60
HDC	regulates	gene	0.60
Cell Cycle	regulates	pathway	0.60
TNF	targets	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
JUN	regulates	gene	0.60
Nfkb	regulates	protein	0.60
CYTOKINES	inhibits	gene	0.60
GNAL	inhibits	gene	0.60
IL8	inhibits	gene	0.60
Rb	inhibits	protein	0.60
CDK2	targets	gene	0.60
GAPDH	targets	gene	0.60
GSK3B	targets	gene	0.60
IL2	targets	gene	0.60
MCL1	targets	gene	0.60
AMPK	associated_with	gene	0.60
Actin	associated_with	protein	0.60
GAPDH	associated_with	gene	0.60
APC	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
Raf	activates	protein	0.60
PDK4	regulates	gene	0.60
MTOR	associated_with	gene	0.60
MIR454	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
VEGFA	targets	gene	0.60
ATG	associated_with	gene	0.60

Incoming (135)

Source	Relation	Type	Str
chromothripsis	upstream_of	process	0.80
MYC	coexpressed_with	gene	0.76
MIR454	associated_with	gene	0.60
ATG	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
CASP3	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
EGFR	expressed_in	gene	0.60
NF-ΚB	activates	gene	0.60
AKT	activates	gene	0.60
EGFR MUTATIONS	expressed_in	gene	0.60
PI3K	activates	gene	0.60
GENES	activates	gene	0.60
BCL2	regulates	gene	0.60
EGFR	activates	gene	0.60
BAMBI	targets	gene	0.60
SOCS3	activates	gene	0.60
MICRORNAS	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
YWHAZ	activates	gene	0.60
MYC	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MYH9	activates	gene	0.60
STAT3	activates	gene	0.60
EGR1	activates	gene	0.60
TBP	activates	gene	0.60
RELA	activates	gene	0.60
PPP5C	regulates	gene	0.60
JUN	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	regulates	gene	0.60
IL6R	regulates	gene	0.60
ABCB1	targets	gene	0.60
ALDH1A1	targets	gene	0.60
ATF3	targets	gene	0.60
AXIN2	targets	gene	0.60
TXNIP	activates	gene	0.60
AXIN1	encodes	gene	0.60
HNF4A	encodes	gene	0.60
MIRNAS	encodes	gene	0.60
MYH9	encodes	gene	0.60
AXIN	associated_with	gene	0.60
TSPAN1	associated_with	gene	0.60
MERTK	regulates	gene	0.60
TNF	inhibits	gene	0.60
IL3	inhibits	gene	0.60
IL1B	inhibits	gene	0.60
CAMKII	inhibits	gene	0.60
BCL2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CCND1 in their description or question text

No additional research found