gene 842 words KG: IL33
Contents

IL33 Gene

🧬 Gene Info
Gene SymbolIL33
Full NameInterleukin-33
Chromosome9p24.1
FunctionIL33 is a cytokine with alarmin function:
Molecular Weight30 kDa
PathwaysMAPK pathway
UniProt IDQ9BY84
NCBI Gene ID90865
Ensembl IDENSG00000144233
OMIM608678
GeneCardsIL33
Human Protein AtlasIL33
N-terminal domainChromatin-binding domain
C-terminal domainCytokine receptor-binding domain
Full-length formBiologically active as nuclear protein
Associated DiseasesALS
InteractionsADRA1A, ADRA2A, ADRB1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
KG Connections76 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

Noradrenergic-Tau Propagation Blockade
Score: 0.71
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Astrocytes
entity · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: associated_with

Knowledge Graph (12 edges)

IL33 activates ZBP1
IL33 inhibits MLKL
IL33 inhibits RIPK3
IL1RL1 activates IL33
AKT implicated_in IL33
IL33 expressed_in EGFR
IL33 activates dural Tregs
IL33 therapeutic_target CD33
CD33 activates IL33
CD33 therapeutic_target IL33

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