Contents

MLKL Gene

🧬 Gene Info

Gene Symbol	MLKL
Chromosome	16q23.1
Protein Family	RHIM domain-containing pseudo-kinase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	~54 kDa
Amino Acids	480 aa
Exons	10
Pathways	Akt, Apoptosis, Autophagy, Cell Division, Ferroptosis
UniProt ID	Q8TBX5
NCBI Gene ID	83568
Ensembl ID	ENSG00000147854
GeneCards	MLKL
Human Protein Atlas	MLKL
Gene Name	Mixed Lineage Kinase Domain-Like
Four-Helix Bundle (4HB)	N-terminal (1-180)
Associated Diseases	ALS, Alzheimer's disease, DEMYELINATION, Inflammation, Ischemia
Known Drugs/Compounds	RAPAMYCIN, METFORMIN, rapamycin, metformin, Necrosulfonamide, HSYA
Interactions	DEPTOR, HMGB1, EGF, MLST8, RICTOR, MTOR
KG Connections	1177 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph