gene 2,124 words KG: IL1RL1 2026-03-21
kind:genesection:genesstate:published
Contents

IL1RL1 Gene

🧬 Gene Info
Gene SymbolIL1RL1
Full NameInterleukin-1 Receptor-Like 1 (ST2)
Chromosome2q12
Protein FamilyIL-1 receptor family
Protein TypeReceptor
FunctionEndogenous alarmin signals danger
Primary ExpressionNuclear localization in structural cells
Molecular Weight63 kDa
Amino Acids556 aa
Exons11
PathwaysMAPK
UniProt IDQ9INT6
NCBI Gene ID9173
Ensembl IDENSG00000115607
OMIM601203
GeneCardsIL1RL1
Human Protein AtlasIL1RL1
Associated DiseasesALS
InteractionsIL33, NRG1, ASTROCYTES, ASTROCYTE, MICROGLIA, ADRA1A
KG Connections42 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.38
Noradrenergic-Tau Propagation Blockade
Score: 0.51
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

IL33 Gene
gene · KG edge: activates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: associated_with
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates
Mitochondria
entity · KG edge: implicated_in
Microglia in Neurodegeneration
entity · KG edge: activates

Knowledge Graph (12 edges)

IL1RL1 implicated_in AKT
IL1RL1 activates IL33
IL1RL1 co_expressed_with IL33
IL1RL1 co_expressed_with NRG1
IL1RL1 interacts_with IL33
IL1RL1 interacts_with NRG1
IL1RL1 regulates IL4
IL1RL1 regulates IL7R
IL1RL1 regulates LC3
IL1RL1 regulates LDH