gene 2,823 words KG: ZBP1 2026-03-29
section:geneskind:genetopic:alzheimerstopic:parkinsonstopic:als
Contents

ZBP1 (Z-DNA Binding Protein 1)

🧬 Gene Info
Gene SymbolZBP1
AliasesDAI, DLM-1, CMTM4
Chromosome6p24.1
Functionis a cytosolic nucleic acid sensor that plays critical roles in innate immune responses, regulated cell death pathways, and inflammation[@takaoka2007; @kuriakose2023].
Molecular Weight46 kDa
Amino Acids429 aa
PathwaysApoptosis, Autophagy, Complement, Epigenetic, Immune Response
UniProt IDQ9H171
NCBI Gene ID23073
Ensembl IDENSG00000185730
GeneCardsZBP1
Human Protein AtlasZBP1
Official NameZ-DNA Binding Protein 1
Transcript Length~3.8 kb
Protein Length429 amino acids (full-length human isoform)
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Atherosclerosis, Inflammation
InteractionsMFN2, GSDMD, RIPK1, RAB7A, CAT, MLKL
KG Connections405 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Microbial Inflammasome Priming Prevention
Score: 0.58
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Cryptic Exon Silencing Restoration
Score: 0.46

Related Analyses (8)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: interacts_with
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activates

Knowledge Graph (12 edges)

ZBP1 activates MFN2
ZBP1 activates GSDMD
ZBP1 activates RIPK1
ZBP1 activates RAB7A
ZBP1 activates CAT
ZBP1 inhibits GSDMD
ZBP1 inhibits MLKL
ZBP1 interacts_with Z-DNA
ZBP1 activates FADD
ZBP1 activates NRF2