gene 1,677 words KG: GABPA 2026-03-27
kind:genesection:genesstate:published
Contents

GABPA - GA Binding Protein Transcription Factor Alpha Subunit

🧬 Gene Info
Gene SymbolGABPA
Full NameGA Binding Protein Transcription Factor Alpha Subunit
Chromosome21q21.3
Protein TypeTranscription Factor
Functionis a member of the ETS (E26 transformation-specific) family of transcription factors.
Molecular Weight~51 kDa
Amino Acids454 aa
Exons11
PathwaysEpigenetic
UniProt IDQ06546
NCBI Gene ID2551
Ensembl IDENSG00000154727
OMIM137143
GeneCardsGABPA
Human Protein AtlasGABPA
Associated Diseasesneurodegeneration
InteractionsKDM5C, MYC, EGFR, ERK1, TERT, CANCER
KG Connections11 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (8)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Packard Center for ALS Research
institution · KG edge: activates
TERT Gene
gene · KG edge: activates
MYC Gene
gene · KG edge: activates
KDM5C (Lysine Demethylase 5C)
gene · KG edge: activates
GABPB1 Gene
gene · KG edge: binds

Knowledge Graph (11 edges)

GABPA activates Als
GABPA activates Cancer
GABPA inhibits Tumor
GABPA activates Glioblastoma
GABPA activates Epigenetic
KDM5C activates GABPA
MYC activates GABPA
EGFR activates GABPA
ERK1 activates GABPA
TERT activates GABPA